C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029167 Ppargc1a 10090 - 5:51454249-51567725 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000031059 Ppargc1a-002 51457982-51553857 nonsense_mediated_decay
  ENSMUST00000127135 Ppargc1a-004 51498141-51567724 protein_coding
  ENSMUST00000132734 Ppargc1a-001 51454249-51553921 protein_coding
  ENSMUST00000151104 Ppargc1a-003 51490200-51567725 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000031059ENSMUST00000127135ENSMUST00000132734ENSMUST00000151104
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000031059 0.415±0.06 0.329±0.13 0.229±0.00 N/A 0.912±0.65 2.414±0.57 5.412±0.26 4.325±1.33 0.310±0.08 0.223±0.05 1.433±0.00 0.323±0.04 0.286±0.00 0.190±0.03
ENSMUST00000127135 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.090±0.00 N/A
ENSMUST00000132734 0.458±0.26 0.244±0.07 0.355±0.12 1.967±0.77 0.521±0.12 1.756±0.37 7.367±0.53 6.742±0.68 1.011±0.67 0.774±0.31 3.367±1.05 0.205±0.12 0.335±0.33 N/A
ENSMUST00000151104 0.691±0.15 0.513±0.26 N/A N/A 0.972±0.28 4.308±1.07 N/A N/A 0.969±0.06 0.592±0.13 N/A 1.137±0.50 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002OU CIL_0002OU_0002 CGP 5:49959951-51567725
CIL_0007ZS CIL_0007ZS_0002 VISTA 5:51291179-51892760
CIL_00033R CIL_00033R_0003 CGP 5:51454249-52190519

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0001666 IEA response to hypoxia
GO:0003677 IDA DNA binding
GO:0003682 IEA chromatin binding
GO:0003713 IMP transcription coactivator activity
GO:0003723 IEA RNA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 IEA cytosol
GO:0006012 IEA galactose metabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006355 ISS regulation of transcription, DNA-templated
GO:0007005 IEA mitochondrion organization
GO:0008134 IPI transcription factor binding
GO:0008209 IEA androgen metabolic process
GO:0009409 IEA response to cold
GO:0010822 IMP positive regulation of mitochondrion organization
GO:0014070 IEA response to organic cyclic compound
GO:0014823 IEA response to activity
GO:0014850 IDA response to muscle activity
GO:0016922 IEA ligand-dependent nuclear receptor binding
GO:0022904 IDA respiratory electron transport chain
GO:0030374 IEA ligand-dependent nuclear receptor transcription coactivator activity
GO:0031325 IEA positive regulation of cellular metabolic process
GO:0031490 IDA chromatin DNA binding
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031667 IEA response to nutrient levels
GO:0032922 IDA circadian regulation of gene expression
GO:0034599 IMP cellular response to oxidative stress
GO:0036273 IEA response to statin
GO:0042493 IEA response to drug
GO:0042594 IEA response to starvation
GO:0042752 IDA regulation of circadian rhythm
GO:0043201 IEA response to leucine
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0043565 ISS sequence-specific DNA binding
GO:0045820 IEA negative regulation of glycolytic process
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046321 IEA positive regulation of fatty acid oxidation
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051552 IEA flavone metabolic process
GO:0071250 IEA cellular response to nitrite
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0071398 IEA cellular response to fatty acid
GO:0071456 IEA cellular response to hypoxia
GO:0071871 IEA response to epinephrine
GO:0071873 IEA response to norepinephrine
GO:0097067 IEA cellular response to thyroid hormone stimulus
GO:1901215 ISS negative regulation of neuron death
GO:1901857 IMP positive regulation of cellular respiration
GO:1901860 IMP positive regulation of mitochondrial DNA metabolic process
GO:1901863 IMP positive regulation of muscle tissue development
GO:2000272 IEA negative regulation of receptor activity
GO:2000310 IEA regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000507 IMP positive regulation of energy homeostasis
GO:2001171 IMP positive regulation of ATP biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000067829 ppargc1a peroxisome proliferator-activated receptor gamma, coactivator 1 alpha protein_coding Danio_rerio
ENSG00000109819 PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha protein_coding Homo_sapiens

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