C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lysine (K)-specific demethylase 2B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029475 Kdm2b 10090 - 5:122870668-123015080 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000031435 Kdm2b-009 122870668-122900355 protein_coding
  ENSMUST00000046073 Kdm2b-001 122870668-122989099 protein_coding
  ENSMUST00000086200 Kdm2b-201 122870681-122988533 protein_coding
  ENSMUST00000118027 Kdm2b-003 122870679-122989306 protein_coding
  ENSMUST00000121739 Kdm2b-002 122871705-122989823 protein_coding
  ENSMUST00000123479 Kdm2b-005 122887847-122989092 retained_intron
  ENSMUST00000127403 Kdm2b-007 122871291-122989794 nonsense_mediated_decay
  ENSMUST00000129998 Kdm2b-008 122883428-122922107 processed_transcript
  ENSMUST00000132419 Kdm2b-017 122880635-122882233 retained_intron
  ENSMUST00000134501 Kdm2b-004 122940615-122989099 retained_intron
  ENSMUST00000138929 Kdm2b-012 122934836-122953117 processed_transcript
  ENSMUST00000139674 Kdm2b-010 122875482-122881085 retained_intron
  ENSMUST00000143273 Kdm2b-015 122932658-122947994 processed_transcript
  ENSMUST00000145082 Kdm2b-013 122932575-122952506 protein_coding
  ENSMUST00000147544 Kdm2b-014 122934856-122951990 processed_transcript
  ENSMUST00000150543 Kdm2b-011 122947735-122984971 processed_transcript
  ENSMUST00000152872 Kdm2b-016 122880508-122888580 protein_coding
  ENSMUST00000156474 Kdm2b-006 122932472-122988536 protein_coding
  ENSMUST00000172729 Kdm2b-020 122987683-123012874 protein_coding
  ENSMUST00000173312 Kdm2b-022 123007579-123015080 processed_transcript
  ENSMUST00000173355 Kdm2b-019 122882216-122917724 processed_transcript
  ENSMUST00000173670 Kdm2b-021 123007464-123012878 processed_transcript
  ENSMUST00000174357 Kdm2b-018 122883438-122921548 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000031435ENSMUST00000046073ENSMUST00000086200ENSMUST00000118027ENSMUST00000121739
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000031435 7.025±3.34 5.621±0.97 6.046±0.21 27.142±2.72 11.737±2.76 7.400±1.24 2.410±0.08 3.548±0.21 5.929±3.33 6.631±0.32 N/A 11.581±3.13 6.860±2.36 8.567±2.18
ENSMUST00000046073 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.350±0.47 1.782±0.00 N/A N/A
ENSMUST00000086200 N/A N/A 4.363±0.55 N/A N/A N/A N/A N/A N/A N/A 1.720±0.48 3.011±0.00 N/A N/A
ENSMUST00000118027 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.159±0.28 1.928±0.39 N/A N/A
ENSMUST00000121739 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.457±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007G4 CIL_0007G4_0003 CGP 5:122850188-123015080
CIL_0007G5 CIL_0007G5_0004 CGP 5:122870668-123030450

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0003677 IEA DNA binding
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0007283 IMP spermatogenesis
GO:0008270 IEA zinc ion binding
GO:0016577 TAS histone demethylation
GO:0019843 IEA rRNA binding
GO:0021555 IMP midbrain-hindbrain boundary morphogenesis
GO:0021592 IMP fourth ventricle development
GO:0021670 IMP lateral ventricle development
GO:0021678 IMP third ventricle development
GO:0021993 IMP initiation of neural tube closure
GO:0030900 IMP forebrain development
GO:0030901 IMP midbrain development
GO:0030902 IMP hindbrain development
GO:0031519 IEA PcG protein complex
GO:0032452 TAS histone demethylase activity
GO:0035518 IEA histone H2A monoubiquitination
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0048596 IMP embryonic camera-type eye morphogenesis
GO:0051864 IEA histone demethylase activity (H3-K36 specific)
GO:0055114 IEA oxidation-reduction process
GO:0070544 IEA histone H3-K36 demethylation
GO:2000178 IMP negative regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000036593 kdm2ba lysine (K)-specific demethylase 2Ba protein_coding Danio_rerio
ENSDARG00000046010 kdm2bb lysine (K)-specific demethylase 2Bb protein_coding Danio_rerio
ENSG00000089094 KDM2B lysine (K)-specific demethylase 2B protein_coding Homo_sapiens

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