C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: p21 protein (Cdc42/Rac)-activated kinase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000033040 Pak1-001 ENSMUSG00000030774 10090 + 7:97842935-97912381 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033040
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033040 2.634±1.96 1.548±0.69 5.376±0.15 49.916±12.54 4.389±0.89 3.798±1.39 0.272±0.07 5.748±3.60 2.253±1.99 2.680±0.35 7.625±0.86 2.187±0.99 2.295±1.34 1.062±0.45

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002Q0 CIL_0002Q0_0003 CGP 7:97842935-98049663

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0001726 IEA ruffle
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0004672 IDA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005515 IEA protein binding
GO:0005518 IEA collagen binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0005886 IEA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005925 TAS focal adhesion
GO:0007528 IGI neuromuscular junction development
GO:0010033 IEA response to organic substance
GO:0014704 IEA intercalated disc
GO:0016020 IEA membrane
GO:0016358 IDA dendrite development
GO:0019901 IEA protein kinase binding
GO:0030018 IEA Z disc
GO:0030424 IDA axon
GO:0030425 IEA dendrite
GO:0030426 IDA growth cone
GO:0031532 IEA actin cytoskeleton reorganization
GO:0031965 IEA nuclear membrane
GO:0032869 IEA cellular response to insulin stimulus
GO:0032956 IEA regulation of actin cytoskeleton organization
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0033148 IEA positive regulation of intracellular estrogen receptor signaling pathway
GO:0042060 IEA wound healing
GO:0043113 IGI receptor clustering
GO:0043234 IEA protein complex
GO:0043507 IEA positive regulation of JUN kinase activity
GO:0046777 IEA protein autophosphorylation
GO:0048754 IEA branching morphogenesis of an epithelial tube
GO:0048812 IEA neuron projection morphogenesis
GO:0051496 IEA positive regulation of stress fiber assembly
GO:0060244 IEA negative regulation of cell proliferation involved in contact inhibition

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000009560 pak1-201 protein_coding Danio_rerio 0 673
ENSDART00000101725 pak1-202 protein_coding Danio_rerio 0 623
ENSDART00000146147 pak1-001 protein_coding Danio_rerio 0 619
ENSDART00000093004 map4k3b-201 protein_coding Danio_rerio 0.00006 55
ENSDART00000157092 map4k3b-001 protein_coding Danio_rerio 0.00006 55
ENSDART00000153571 map4k3b-002 retained_intron Danio_rerio 0.00006 55
ENST00000278568 PAK1-002 protein_coding Homo_sapiens 0 2226
ENST00000356341 PAK1-001 protein_coding Homo_sapiens 0 3001
ENST00000524847 PAK1-007 protein_coding Homo_sapiens 0 479
ENST00000525542 PAK1-005 processed_transcript Homo_sapiens 0 1158
ENST00000526103 PAK1-016 retained_intron Homo_sapiens 0 342
ENST00000526910 PAK1-012 retained_intron Homo_sapiens 0 420
ENST00000526968 PAK1-006 protein_coding Homo_sapiens 6e-37 158
ENST00000527457 PAK1-014 nonsense_mediated_decay Homo_sapiens 0 667
ENST00000527535 PAK1-019 nonsense_mediated_decay Homo_sapiens 0 778
ENST00000528203 PAK1-004 protein_coding Homo_sapiens 0 1906
ENST00000528592 PAK1-011 protein_coding Homo_sapiens 0 425
ENST00000528633 PAK1-010 protein_coding Homo_sapiens 0 320
ENST00000529248 PAK1-009 protein_coding Homo_sapiens 0 510
ENST00000530358 PAK1-015 retained_intron Homo_sapiens 0 394
ENST00000530617 PAK1-003 protein_coding Homo_sapiens 0 2255
ENST00000532711 PAK1-020 retained_intron Homo_sapiens 0 359
ENST00000532991 PAK1-017 retained_intron Homo_sapiens 0 780
ENST00000533285 PAK1-018 protein_coding Homo_sapiens 0 1027
ENST00000533568 PAK1-008 retained_intron Homo_sapiens 0 863

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