C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin linked kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030890 Ilk 10090 + 7:105736592-105742925 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033182 Ilk-001 105736592-105742925 protein_coding
  ENSMUST00000127298 Ilk-008 105740511-105741908 protein_coding
  ENSMUST00000130565 Ilk-012 105741583-105742776 retained_intron
  ENSMUST00000136687 Ilk-004 105736733-105741043 protein_coding
  ENSMUST00000138150 Ilk-010 105741781-105742657 processed_transcript
  ENSMUST00000145123 Ilk-006 105737101-105741361 retained_intron
  ENSMUST00000148971 Ilk-007 105740188-105741764 retained_intron
  ENSMUST00000149695 Ilk-002 105736671-105742918 retained_intron
  ENSMUST00000151108 Ilk-009 105740972-105741910 retained_intron
  ENSMUST00000152508 Ilk-011 105741182-105742096 retained_intron
  ENSMUST00000153557 Ilk-003 105740511-105741174 retained_intron
  ENSMUST00000154626 Ilk-005 105737123-105741475 retained_intron
  ENSMUST00000163389 Ilk-201 105736725-105742925 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENSMUST00000033182ENSMUST00000127298ENSMUST00000163389
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000033182 42.964±9.57 34.949±0.27 76.439±7.32 28.437±5.61 28.425±5.92 17.428±0.00 14.475±1.92 22.690±2.14 17.260±6.11 27.883±6.45 9.930±1.06 44.425±4.14 41.598±14.67
ENSMUST00000127298 N/A N/A N/A 37.299±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 112.315±37.66
ENSMUST00000163389 N/A N/A 44.809±5.14 N/A N/A N/A N/A N/A N/A N/A N/A 61.828±10.51 49.592±2.77

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001I3 CIL_0001I3_0002 CGP 7:105640562-105737376
CIL_0001HZ CIL_0001HZ_0002 CGP 7:105732207-105742925
CIL_0003X8 CIL_0003X8_0002 CGP 7:105736592-105744361

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001558 IEA regulation of cell growth
GO:0001658 IDA branching involved in ureteric bud morphogenesis
GO:0001725 IEA stress fiber
GO:0001954 IEA positive regulation of cell-matrix adhesion
GO:0004674 ISO protein serine/threonine kinase activity
GO:0004871 IEA signal transducer activity
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005886 IEA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005925 ISA focal adhesion
GO:0006469 IEA negative regulation of protein kinase activity
GO:0007050 IEA cell cycle arrest
GO:0007229 ISO integrin-mediated signaling pathway
GO:0007569 IEA cell aging
GO:0008284 IMP positive regulation of cell proliferation
GO:0010667 IEA negative regulation of cardiac muscle cell apoptotic process
GO:0010761 IMP fibroblast migration
GO:0014044 IMP Schwann cell development
GO:0014912 IEA negative regulation of smooth muscle cell migration
GO:0016020 IEA membrane
GO:0017124 IEA SH3 domain binding
GO:0018105 IMP peptidyl-serine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0021675 IMP nerve development
GO:0022011 IMP myelination in peripheral nervous system
GO:0030027 IDA lamellipodium
GO:0030030 IMP cell projection organization
GO:0030054 IEA cell junction
GO:0030335 IEA positive regulation of cell migration
GO:0030424 IEA axon
GO:0030513 IMP positive regulation of BMP signaling pathway
GO:0032288 IEA myelin assembly
GO:0032956 IEA regulation of actin cytoskeleton organization
GO:0034446 IEA substrate adhesion-dependent cell spreading
GO:0042327 IEA positive regulation of phosphorylation
GO:0043025 IEA neuronal cell body
GO:0043034 IEA costamere
GO:0043066 IEA negative regulation of apoptotic process
GO:0043195 IEA terminal bouton
GO:0043198 IEA dendritic shaft
GO:0043206 IEA extracellular fibril organization
GO:0043234 IEA protein complex
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0043410 IEA positive regulation of MAPK cascade
GO:0043491 IMP protein kinase B signaling
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0045197 IMP establishment or maintenance of epithelial cell apical/basal polarity
GO:0045663 IEA positive regulation of myoblast differentiation
GO:0045669 IMP positive regulation of osteoblast differentiation
GO:0045773 IEA positive regulation of axon extension
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0048662 IEA negative regulation of smooth muscle cell proliferation
GO:0048812 IEA neuron projection morphogenesis
GO:0050772 IEA positive regulation of axonogenesis
GO:0050775 IEA positive regulation of dendrite morphogenesis
GO:0051291 IEA protein heterooligomerization
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0070527 IEA platelet aggregation
GO:0090263 IEA positive regulation of canonical Wnt signaling pathway
GO:2000178 IGI negative regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056964 ilk integrin linked kinase protein_coding Danio_rerio
ENSG00000166333 ILK integrin-linked kinase protein_coding Homo_sapiens

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