C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin-linked kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000166333 ILK 9606 + 11:6603708-6610874 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000299421 ILK-001 6603731-6610870 protein_coding
  ENST00000396751 ILK-003 6603816-6610870 protein_coding
  ENST00000420936 ILK-002 6603758-6610833 protein_coding
  ENST00000524735 ILK-012 6607671-6608418 processed_transcript
  ENST00000526114 ILK-009 6603773-6609156 nonsense_mediated_decay
  ENST00000526318 ILK-013 6604296-6610871 protein_coding
  ENST00000526711 ILK-006 6603731-6610874 nonsense_mediated_decay
  ENST00000527121 ILK-008 6603782-6609393 nonsense_mediated_decay
  ENST00000528784 ILK-011 6608266-6610031 retained_intron
  ENST00000528995 ILK-005 6603787-6610866 protein_coding
  ENST00000530016 ILK-007 6603774-6610611 retained_intron
  ENST00000532063 ILK-201 6603708-6610874 protein_coding
  ENST00000534565 ILK-010 6603796-6604726 processed_transcript
  ENST00000534706 ILK-014 6608746-6609815 processed_transcript
  ENST00000537806 ILK-004 6603744-6610835 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartLiverLungMuscleOvaryPlacentaTestisENST00000299421ENST00000396751ENST00000420936ENST00000527121ENST00000528784ENST00000532063
Transcript ID Adipose Adrenal Brain Breast Colon Heart Liver Lung Muscle Ovary Placenta Testis
ENST00000299421 N/A N/A N/A 5.949±0.00 N/A 2.126±0.00 7.017±0.00 N/A N/A N/A N/A N/A
ENST00000396751 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.356±0.00 N/A N/A
ENST00000420936 19.763±0.00 26.955±0.00 2.769±0.00 30.178±0.00 28.885±24.20 13.951±11.50 7.657±0.00 2.939±0.00 N/A 66.023±0.00 58.122±28.91 30.022±0.00
ENST00000527121 N/A N/A N/A N/A 6.357±0.00 3.415±0.00 11.316±0.00 4.209±0.00 4.800±0.00 N/A 24.446±0.00 N/A
ENST00000528784 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 26.162±0.00 N/A
ENST00000532063 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 12.306±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001HZ CIL_0001HZ_0001 CGP 11:6595075-6610874
CIL_0003X8 CIL_0003X8_0001 CGP 11:6603708-6612667

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001558 IEA regulation of cell growth
GO:0001658 IEA branching involved in ureteric bud morphogenesis
GO:0001725 IEA stress fiber
GO:0001954 IEA positive regulation of cell-matrix adhesion
GO:0004672 IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004871 IEA signal transducer activity
GO:0005178 IEA integrin binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005925 IDA focal adhesion
GO:0006468 IDA:IEA protein phosphorylation
GO:0006469 IEA negative regulation of protein kinase activity
GO:0007050 IEA cell cycle arrest
GO:0007160 TAS cell-matrix adhesion
GO:0007229 IDA integrin-mediated signaling pathway
GO:0007569 IEA cell aging
GO:0008283 NAS cell proliferation
GO:0008284 IEA positive regulation of cell proliferation
GO:0009966 IEA regulation of signal transduction
GO:0010667 IEA negative regulation of cardiac muscle cell apoptotic process
GO:0010761 IEA fibroblast migration
GO:0014044 IEA Schwann cell development
GO:0014912 IEA negative regulation of smooth muscle cell migration
GO:0016020 IDA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017124 IEA SH3 domain binding
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0021675 IEA nerve development
GO:0022011 IEA myelination in peripheral nervous system
GO:0030027 IEA lamellipodium
GO:0030030 IEA cell projection organization
GO:0030054 IDA cell junction
GO:0030335 IEA positive regulation of cell migration
GO:0030424 IEA axon
GO:0030513 IEA positive regulation of BMP signaling pathway
GO:0032288 IEA myelin assembly
GO:0032956 IEA regulation of actin cytoskeleton organization
GO:0034329 TAS cell junction assembly
GO:0034446 IMP substrate adhesion-dependent cell spreading
GO:0042327 IMP positive regulation of phosphorylation
GO:0043025 IEA neuronal cell body
GO:0043034 IEA costamere
GO:0043066 IEA negative regulation of apoptotic process
GO:0043195 IEA terminal bouton
GO:0043198 IEA dendritic shaft
GO:0043206 IEA extracellular fibril organization
GO:0043234 IEA protein complex
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0043410 IEA positive regulation of MAPK cascade
GO:0043491 IEA protein kinase B signaling
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0045197 IEA establishment or maintenance of epithelial cell apical/basal polarity
GO:0045663 IEA positive regulation of myoblast differentiation
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045773 IEA positive regulation of axon extension
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0048662 IEA negative regulation of smooth muscle cell proliferation
GO:0048812 IEA neuron projection morphogenesis
GO:0050772 IEA positive regulation of axonogenesis
GO:0050775 IEA positive regulation of dendrite morphogenesis
GO:0051291 IEA protein heterooligomerization
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0070527 IMP platelet aggregation
GO:0090263 IMP positive regulation of canonical Wnt signaling pathway
GO:2000178 IEA negative regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056964 ilk integrin linked kinase protein_coding Danio_rerio
ENSMUSG00000030890 Ilk integrin linked kinase protein_coding Mus_musculus

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