C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031012 Cask 10090 - X:13517080-13851367 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033321 Cask-002 13521331-13846556 protein_coding
  ENSMUST00000115435 Cask-005 13521782-13526768 protein_coding
  ENSMUST00000115436 Cask-201 13517080-13846541 protein_coding
  ENSMUST00000115438 Cask-001 13517080-13846578 protein_coding
  ENSMUST00000124710 Cask-006 13626280-13846088 protein_coding
  ENSMUST00000128012 Cask-011 13571103-13677594 protein_coding
  ENSMUST00000128095 Cask-004 13522080-13537669 protein_coding
  ENSMUST00000132240 Cask-009 13714731-13851367 processed_transcript
  ENSMUST00000139735 Cask-008 13533340-13559331 protein_coding
  ENSMUST00000152358 Cask-010 13554584-13846578 retained_intron
  ENSMUST00000155989 Cask-007 13846090-13846735 processed_transcript
  ENSMUST00000156096 Cask-003 13517080-13786030 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033321ENSMUST00000115436ENSMUST00000115438ENSMUST00000128012ENSMUST00000128095ENSMUST00000152358ENSMUST00000156096
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033321 1.735±0.34 0.521±0.09 2.979±0.40 5.462±0.00 1.370±0.29 2.692±0.40 0.540±0.16 1.260±0.23 0.926±0.47 1.221±0.34 0.824±0.18 3.614±1.34 0.727±0.36 0.174±0.05
ENSMUST00000115436 1.230±0.13 N/A 0.822±0.00 N/A 0.624±0.24 N/A 0.554±0.15 0.463±0.07 0.212±0.06 1.771±0.00 0.527±0.15 0.724±0.04 N/A 0.087±0.00
ENSMUST00000115438 0.810±0.18 0.879±0.16 0.687±0.00 2.992±0.91 0.689±0.30 2.153±0.00 0.184±0.03 0.537±0.23 0.257±0.06 0.488±0.00 0.221±0.09 0.946±0.36 0.118±0.05 0.033±0.00
ENSMUST00000128012 N/A N/A N/A 31.633±0.00 N/A N/A N/A N/A N/A N/A N/A 19.218±0.00 3.644±0.67 1.340±0.00
ENSMUST00000128095 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.215±0.00 0.343±0.00
ENSMUST00000152358 N/A 0.921±0.19 N/A N/A N/A 1.843±0.05 N/A N/A N/A 1.386±0.00 N/A 2.442±0.48 N/A 0.160±0.00
ENSMUST00000156096 N/A N/A 1.521±0.00 1.375±0.00 0.650±0.18 N/A 0.290±0.00 0.517±0.14 0.262±0.17 1.583±0.70 0.435±0.21 1.911±0.99 0.146±0.05 0.059±0.04

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007LW CIL_0007LW_0002 UCNEbase X:13169486-13522078
CIL_0001X6 CIL_0001X6_0003 CGP X:13466110-13851367
CIL_0001JA CIL_0001JA_0003 CGP X:13517080-13851367

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001953 IEA negative regulation of cell-matrix adhesion
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005516 IEA calmodulin binding
GO:0005524 IEA ATP binding
GO:0005604 IDA basement membrane
GO:0005634 IDA nucleus
GO:0005652 IEA nuclear lamina
GO:0005730 IEA nucleolus
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0005911 IDA cell-cell junction
GO:0005925 IEA focal adhesion
GO:0006468 IEA protein phosphorylation
GO:0010839 IEA negative regulation of keratinocyte proliferation
GO:0016020 IDA membrane
GO:0016323 IDA basolateral plasma membrane
GO:0016363 IEA nuclear matrix
GO:0042043 IDA neurexin family protein binding
GO:0045202 IDA synapse
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0061045 IEA negative regulation of wound healing
GO:0070509 IMP calcium ion import
GO:0090280 IDA positive regulation of calcium ion import
GO:0090288 IEA negative regulation of cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000035103 caskb calcium/calmodulin-dependent serine protein kinase b protein_coding Danio_rerio
ENSDARG00000059809 caska calcium/calmodulin-dependent serine protein kinase a protein_coding Danio_rerio
ENSG00000147044 CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein_coding Homo_sapiens

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