C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000147044 CASK 9606 - X:41514934-41923463 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000378154 CASK-006 41559497-41923463 protein_coding
  ENST00000378158 CASK-001 41519653-41923339 protein_coding
  ENST00000378163 CASK-007 41519265-41923463 protein_coding
  ENST00000378166 CASK-005 41520090-41923015 protein_coding
  ENST00000378168 CASK-012 41519549-41561627 protein_coding
  ENST00000378179 CASK-002 41519527-41589951 protein_coding
  ENST00000421587 CASK-004 41514934-41923012 protein_coding
  ENST00000442742 CASK-013 41520336-41923007 protein_coding
  ENST00000468986 CASK-008 41743613-41923015 processed_transcript
  ENST00000469265 CASK-011 41635728-41665431 processed_transcript
  ENST00000472704 CASK-003 41552605-41578453 processed_transcript
  ENST00000477823 CASK-009 41786810-41922982 processed_transcript
  ENST00000486402 CASK-010 41660101-41665832 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000378154ENST00000378158ENST00000378163ENST00000378166ENST00000378168ENST00000378179ENST00000421587ENST00000442742ENST00000469265
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000378154 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.199±0.00 N/A N/A N/A N/A
ENST00000378158 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.297±0.00 N/A 0.362±0.00
ENST00000378163 1.125±0.00 2.188±0.00 0.584±0.00 N/A 1.355±0.00 2.164±0.65 0.679±0.00 1.643±1.19 0.792±0.00 1.805±0.00 0.239±0.00 2.002±0.11 0.656±0.16 1.321±0.00
ENST00000378166 N/A N/A N/A 0.860±0.00 N/A N/A 0.427±0.00 N/A N/A 2.092±0.00 1.093±0.00 N/A N/A N/A
ENST00000378168 N/A N/A N/A N/A 4.052±0.00 4.952±0.00 N/A 2.800±0.00 1.937±0.00 N/A N/A 9.583±0.00 N/A N/A
ENST00000378179 N/A N/A 1.326±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000421587 1.391±0.00 2.477±0.00 0.394±0.00 1.510±1.15 1.276±0.54 1.454±0.10 0.586±0.00 1.115±0.52 0.656±0.04 1.287±0.26 0.278±0.16 2.441±0.98 0.761±0.10 0.768±0.43
ENST00000442742 2.351±0.00 N/A N/A 3.438±0.84 2.209±0.00 N/A 1.061±0.00 N/A N/A 1.716±0.00 1.038±0.00 6.721±0.00 0.895±0.22 1.416±0.00
ENST00000469265 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 13.254±0.00 7.687±0.00 2.231±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007LW CIL_0007LW_0001 UCNEbase X:41232520-41520330
CIL_0001X6 CIL_0001X6_0002 CGP X:41447434-41923463
CIL_0001JA CIL_0001JA_0002 CGP X:41514934-41923463

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001953 IMP negative regulation of cell-matrix adhesion
GO:0004385 TAS guanylate kinase activity
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IEA protein binding
GO:0005516 IEA calmodulin binding
GO:0005524 IEA ATP binding
GO:0005604 IDA basement membrane
GO:0005634 IEA nucleus
GO:0005652 IDA nuclear lamina
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0005886 TAS plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005925 IDA focal adhesion
GO:0006468 IEA protein phosphorylation
GO:0007155 TAS cell adhesion
GO:0010839 IMP negative regulation of keratinocyte proliferation
GO:0015629 TAS actin cytoskeleton
GO:0016020 IEA membrane
GO:0016323 IEA basolateral plasma membrane
GO:0016363 IDA nuclear matrix
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030198 TAS extracellular matrix organization
GO:0042043 IEA neurexin family protein binding
GO:0042734 ISS presynaptic membrane
GO:0045202 IEA synapse
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046939 TAS nucleotide phosphorylation
GO:0060170 ISS ciliary membrane
GO:0061045 IMP negative regulation of wound healing
GO:0070509 IEA calcium ion import
GO:0090280 IEA positive regulation of calcium ion import
GO:0090288 IMP negative regulation of cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000035103 caskb calcium/calmodulin-dependent serine protein kinase b protein_coding Danio_rerio
ENSDARG00000059809 caska calcium/calmodulin-dependent serine protein kinase a protein_coding Danio_rerio
ENSMUSG00000031012 Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein_coding Mus_musculus

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