C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cullin 4A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031446 Cul4a 10090 + 8:13105621-13147940 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000016680 Cul4a-001 13105621-13147940 protein_coding
  ENSMUST00000121426 Cul4a-002 13105740-13124222 protein_coding
  ENSMUST00000125514 Cul4a-004 13123525-13147362 nonsense_mediated_decay
  ENSMUST00000125646 Cul4a-006 13144225-13147940 retained_intron
  ENSMUST00000135371 Cul4a-003 13105740-13117195 retained_intron
  ENSMUST00000139316 Cul4a-008 13139843-13142592 retained_intron
  ENSMUST00000141315 Cul4a-007 13105936-13121746 retained_intron
  ENSMUST00000142700 Cul4a-005 13140307-13146619 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000016680ENSMUST00000121426ENSMUST00000125514ENSMUST00000125646ENSMUST00000135371
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000016680 25.387±1.81 25.354±2.02 22.632±1.46 18.916±7.19 14.847±3.33 13.657±2.34 17.666±1.23 15.840±1.42 24.824±7.34 16.243±0.27 23.205±1.10 31.037±7.02 21.677±6.37 25.379±5.21
ENSMUST00000121426 N/A 43.463±6.66 N/A N/A 10.630±1.09 8.193±0.71 N/A N/A N/A N/A N/A 23.087±4.06 N/A N/A
ENSMUST00000125514 N/A N/A N/A 5.950±0.00 N/A 4.685±0.00 N/A N/A N/A N/A N/A 19.238±6.20 5.373±1.32 N/A
ENSMUST00000125646 N/A 52.763±6.17 N/A N/A 11.964±0.87 11.858±2.14 N/A 7.971±2.56 13.264±1.78 10.975±2.89 N/A N/A N/A N/A
ENSMUST00000135371 N/A N/A N/A N/A 4.118±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005GG CIL_0005GG_0002 CGP 8:13077189-13147940
CIL_0000QK CIL_0000QK_0002 CGP 8:13105621-13175338

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0006281 IEA DNA repair
GO:0006511 IMP ubiquitin-dependent protein catabolic process
GO:0008284 IDA positive regulation of cell proliferation
GO:0016032 IEA viral process
GO:0016567 IEA protein ubiquitination
GO:0030097 IMP hemopoiesis
GO:0030853 IDA negative regulation of granulocyte differentiation
GO:0031461 IEA cullin-RING ubiquitin ligase complex
GO:0031464 ISS Cul4A-RING E3 ubiquitin ligase complex
GO:0031625 IEA ubiquitin protein ligase binding
GO:0035019 IMP somatic stem cell maintenance
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732 ISO positive regulation of protein catabolic process
GO:0051246 IMP regulation of protein metabolic process
GO:0080008 ISS Cul4-RING E3 ubiquitin ligase complex
GO:1900087 IMP positive regulation of G1/S transition of mitotic cell cycle
GO:2000001 IMP regulation of DNA damage checkpoint
GO:2000819 IMP regulation of nucleotide-excision repair

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000024452 cul4a cullin 4A protein_coding Danio_rerio
ENSG00000139842 CUL4A cullin 4A protein_coding Homo_sapiens

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