C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: neural precursor cell expressed, developmentally down-regulated 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000034740 Nedd4-001 ENSMUSG00000032216 10090 + 9:72662346-72749852 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000034740
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000034740 181.114±30.49 59.365±14.24 149.802±35.64 131.191±33.03 115.933±21.39 54.665±5.58 77.101±6.68 61.688±7.78 49.265±20.59 88.878±9.83 63.537±6.82 174.974±53.95 104.565±13.62 13.525±2.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004U3 CIL_0004U3_0002 CGP 9:72662346-72917291

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000151 IPI ubiquitin ligase complex
GO:0000785 IEA chromatin
GO:0002250 IMP adaptive immune response
GO:0003151 IGI outflow tract morphogenesis
GO:0003197 IGI endocardial cushion development
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005634 IBA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0005938 IEA cell cortex
GO:0006513 IDA protein monoubiquitination
GO:0006622 IEA protein targeting to lysosome
GO:0007041 IEA lysosomal transport
GO:0007528 IMP neuromuscular junction development
GO:0010766 IDA negative regulation of sodium ion transport
GO:0010768 IEA negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IDA membrane
GO:0016567 IDA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0019089 IEA transmission of virus
GO:0019871 IDA sodium channel inhibitor activity
GO:0019904 IEA protein domain specific binding
GO:0030948 IDA negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031175 IEA neuron projection development
GO:0031623 IEA receptor internalization
GO:0031698 IEA beta-2 adrenergic receptor binding
GO:0032801 IEA receptor catabolic process
GO:0034644 IEA cellular response to UV
GO:0034765 IEA regulation of ion transmembrane transport
GO:0042110 IMP T cell activation
GO:0042391 IEA regulation of membrane potential
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042921 IEA glucocorticoid receptor signaling pathway
GO:0043130 IEA ubiquitin binding
GO:0043162 IEA ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0044111 IEA development involved in symbiotic interaction
GO:0045732 IDA positive regulation of protein catabolic process
GO:0046824 IEA positive regulation of nucleocytoplasmic transport
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048514 IGI blood vessel morphogenesis
GO:0048814 IMP regulation of dendrite morphogenesis
GO:0050807 IMP regulation of synapse organization
GO:0050815 IDA phosphoserine binding
GO:0050816 IDA phosphothreonine binding
GO:0050847 IEA progesterone receptor signaling pathway
GO:0070062 IEA extracellular vesicular exosome
GO:0070063 IEA RNA polymerase binding
GO:0070064 IPI proline-rich region binding
GO:0070534 ISS protein K63-linked ubiquitination
GO:1901016 IEA regulation of potassium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000084061 nedd4l-201 protein_coding Danio_rerio 0 569
ENSDART00000146576 nedd4l-001 protein_coding Danio_rerio 0 558
ENST00000338963 NEDD4-001 protein_coding Homo_sapiens 0 1526
ENST00000435532 NEDD4-006 protein_coding Homo_sapiens 0 1526
ENST00000502612 NEDD4-009 nonsense_mediated_decay Homo_sapiens 0 636
ENST00000503468 NEDD4-005 nonsense_mediated_decay Homo_sapiens 0 918
ENST00000506154 NEDD4-003 protein_coding Homo_sapiens 0 1526
ENST00000507063 NEDD4-007 nonsense_mediated_decay Homo_sapiens 0 429
ENST00000508342 NEDD4-002 protein_coding Homo_sapiens 0 1526
ENST00000508871 NEDD4-004 protein_coding Homo_sapiens 0 1526
ENST00000514893 NEDD4-011 processed_transcript Homo_sapiens 0 595

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