C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sodium channel, voltage-gated, type V, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032511 Scn5a 10090 - 9:119483408-119579016 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000065196 Scn5a-201 119483408-119562678 protein_coding
  ENSMUST00000117911 Scn5a-001 119483410-119579016 protein_coding
  ENSMUST00000120420 Scn5a-002 119484324-119579016 protein_coding
  ENSMUST00000138934 Scn5a-003 119562537-119563503 protein_coding

Mus musculus EnsemblGRCm38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000065196ENSMUST00000117911ENSMUST00000120420ENSMUST00000138934
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000065196 N/A 0.098±0.02 N/A N/A 0.086±0.01 19.739±7.56 0.127±0.05 0.028±0.00 N/A 0.104±0.04 0.284±0.04 0.091±0.06 0.109±0.05
ENSMUST00000117911 0.107±0.00 0.072±0.03 0.138±0.00 0.396±0.00 0.148±0.00 N/A N/A 0.014±0.00 N/A N/A 0.228±0.12 0.075±0.06 N/A
ENSMUST00000120420 0.233±0.07 0.049±0.02 0.067±0.00 0.491±0.13 0.124±0.05 11.500±2.29 0.147±0.03 0.010±0.01 0.964±0.17 0.076±0.05 0.406±0.21 0.021±0.00 0.200±0.10
ENSMUST00000138934 N/A 0.495±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008BE CIL_0008BE_0002 VISTA 9:119196374-119798584
CIL_0005VU CIL_0005VU_0002 CGP 9:119444923-119579016
CIL_0004RF CIL_0004RF_0002 CGP 9:119483408-119719032

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001518 IC voltage-gated sodium channel complex
GO:0003231 IMP cardiac ventricle development
GO:0005248 IDA voltage-gated sodium channel activity
GO:0005515 IPI protein binding
GO:0005516 IEA calmodulin binding
GO:0005886 IDA plasma membrane
GO:0006814 IDA sodium ion transport
GO:0009986 IDA cell surface
GO:0014070 IMP response to organic cyclic compound
GO:0014704 IDA intercalated disc
GO:0016021 ISS integral component of membrane
GO:0019228 IBA neuronal action potential
GO:0030315 IDA T-tubule
GO:0034706 IPI sodium channel complex
GO:0034765 IEA regulation of ion transmembrane transport
GO:0035725 IEA:IDA sodium ion transmembrane transport
GO:0071277 ISS cellular response to calcium ion
GO:0086004 IMP regulation of cardiac muscle cell contraction
GO:0086006 IMP voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086012 IMP membrane depolarization during cardiac muscle cell action potential
GO:0086046 IMP membrane depolarization during SA node cell action potential
GO:0086063 IMP voltage-gated sodium channel activity involved in SA node cell action potential
GO:0086091 IMP regulation of heart rate by cardiac conduction
GO:0097110 IPI scaffold protein binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078758 SCN11A sodium channel, voltage-gated, type XI, alpha subunit protein_coding Danio_rerio
ENSG00000183873 SCN5A sodium channel, voltage-gated, type V, alpha subunit protein_coding Homo_sapiens

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