C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: sodium channel, voltage-gated, type V, alpha
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000120420 Scn5a-002 ENSMUSG00000032511 10090 - 9:119484324-119579016 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000120420
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000120420 0.233±0.07 0.049±0.02 0.067±0.00 0.491±0.13 0.124±0.05 11.500±2.29 0.147±0.03 0.010±0.01 0.964±0.17 0.076±0.05 0.406±0.21 0.021±0.00 0.200±0.10

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008BE CIL_0008BE_0002 VISTA 9:119196374-119798584
CIL_0005VU CIL_0005VU_0002 CGP 9:119444923-119579016
CIL_0004RF CIL_0004RF_0002 CGP 9:119483408-119719032

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001518 IC voltage-gated sodium channel complex
GO:0003231 IMP cardiac ventricle development
GO:0005248 IDA voltage-gated sodium channel activity
GO:0005515 IPI protein binding
GO:0005516 IEA calmodulin binding
GO:0005886 IDA plasma membrane
GO:0006814 IDA sodium ion transport
GO:0009986 IDA cell surface
GO:0014070 IMP response to organic cyclic compound
GO:0014704 IDA intercalated disc
GO:0016021 ISS integral component of membrane
GO:0019228 IBA neuronal action potential
GO:0030315 IDA T-tubule
GO:0034706 IPI sodium channel complex
GO:0034765 IEA regulation of ion transmembrane transport
GO:0035725 IDA:IEA sodium ion transmembrane transport
GO:0071277 ISS cellular response to calcium ion
GO:0086004 IMP regulation of cardiac muscle cell contraction
GO:0086006 IMP voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086012 IMP membrane depolarization during cardiac muscle cell action potential
GO:0086046 IMP membrane depolarization during SA node cell action potential
GO:0086063 IMP voltage-gated sodium channel activity involved in SA node cell action potential
GO:0086091 IMP regulation of heart rate by cardiac conduction
GO:0097110 IPI scaffold protein binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000022042 scn8aa-001 protein_coding Danio_rerio 0 942
ENSDART00000097722 SCN11A-201 protein_coding Danio_rerio 0 885
ENSDART00000022761 scn8ab-201 protein_coding Danio_rerio 0 425
ENSDART00000151299 scn8ab-001 protein_coding Danio_rerio 0 425
ENSDART00000022382 SCN3A-202 protein_coding Danio_rerio 0 374
ENSDART00000011718 scn1a-201 protein_coding Danio_rerio 0 292
ENSDART00000090979 scn1a-202 protein_coding Danio_rerio 0 292
ENST00000327956 SCN5A-006 protein_coding Homo_sapiens 0 331
ENST00000333535 SCN5A-014 protein_coding Homo_sapiens 0 7805
ENST00000354534 SCN8A-001 protein_coding Homo_sapiens 0 976
ENST00000355133 SCN8A-005 protein_coding Homo_sapiens 0 976
ENST00000413689 SCN5A-001 protein_coding Homo_sapiens 0 7697
ENST00000414099 SCN5A-004 protein_coding Homo_sapiens 0 5138
ENST00000423572 SCN5A-003 protein_coding Homo_sapiens 0 7725
ENST00000425664 SCN5A-201 protein_coding Homo_sapiens 0 5291
ENST00000435607 SCN4A-201 protein_coding Homo_sapiens 0 1639
ENST00000443581 SCN5A-202 protein_coding Homo_sapiens 0 7858
ENST00000449082 SCN10A-001 protein_coding Homo_sapiens 0 1607
ENST00000449557 SCN5A-010 protein_coding Homo_sapiens 0 3975
ENST00000450102 SCN5A-008 protein_coding Homo_sapiens 0 3849
ENST00000451551 SCN5A-203 protein_coding Homo_sapiens 0 4004
ENST00000455624 SCN5A-002 protein_coding Homo_sapiens 0 5794
ENST00000464652 SCN5A-011 processed_transcript Homo_sapiens 0 381
ENST00000476683 SCN5A-013 retained_intron Homo_sapiens 0 375
ENST00000491944 SCN5A-005 retained_intron Homo_sapiens 0 1014
ENST00000545061 SCN8A-201 protein_coding Homo_sapiens 0 976
ENST00000548086 SCN8A-006 processed_transcript Homo_sapiens 7e-26 121
ENST00000578147 SCN4A-001 protein_coding Homo_sapiens 0 1628
ENST00000599343 SCN8A-202 protein_coding Homo_sapiens 0 976
ENST00000612060 SCN5A-204 protein_coding Homo_sapiens 0 854

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