C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: WNK lysine deficient protein kinase 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000103108 Wnk4-001 ENSMUSG00000035112 10090 + 11:101260598-101277409 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000103108
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000103108 2.070±1.43 0.108±0.05 2.325±0.92 1.153±0.05 0.182±0.04 6.083±1.46 2.022±1.16 19.870±8.60 1.823±1.29 1.803±0.39 0.068±0.00 2.158±0.84 3.489±2.09 1.061±0.40

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004HC CIL_0004HC_0002 CGP 11:101253707-101277409
CIL_0005SA CIL_0005SA_0002 CGP 11:101260567-101279114

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 ISS ATP binding
GO:0005737 IDA cytoplasm
GO:0005923 IDA tight junction
GO:0006468 ISS protein phosphorylation
GO:0006811 IDA ion transport
GO:0006821 IDA chloride transport
GO:0008104 IDA protein localization
GO:0019869 IEA chloride channel inhibitor activity
GO:0030644 TAS cellular chloride ion homeostasis
GO:0035556 ISS intracellular signal transduction
GO:0050794 IDA regulation of cellular process
GO:0050801 ISS ion homeostasis
GO:0070294 ISS renal sodium ion absorption
GO:0072156 ISS distal tubule morphogenesis
GO:0090188 IMP negative regulation of pancreatic juice secretion

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000246914 WNK4-001 protein_coding Homo_sapiens 0 3847
ENST00000586680 COA3-002 nonsense_mediated_decay Homo_sapiens 0 420
ENST00000587705 WNK4-006 processed_transcript Homo_sapiens 0 503
ENST00000591448 WNK4-002 nonsense_mediated_decay Homo_sapiens 0 2473
ENST00000592072 WNK4-004 retained_intron Homo_sapiens 0 503
ENST00000592669 WNK4-005 retained_intron Homo_sapiens 0 307

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