C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: microphthalmia-associated transcription factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000035158 Mitf 10090 + 6:97807058-98021349 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000043628 Mitf-006 97991792-98018707 protein_coding
  ENSMUST00000043637 Mitf-001 97807058-98021349 protein_coding
  ENSMUST00000101123 Mitf-003 97929799-98018707 protein_coding
  ENSMUST00000113339 Mitf-005 97940918-98018707 protein_coding
  ENSMUST00000139462 Mitf-007 97991819-98018497 nonsense_mediated_decay
  ENSMUST00000144641 Mitf-004 97938494-97941128 processed_transcript
  ENSMUST00000148233 Mitf-002 97807058-97942179 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000043628ENSMUST00000043637ENSMUST00000101123ENSMUST00000113339ENSMUST00000139462ENSMUST00000148233
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000043628 N/A N/A N/A 2.341±0.00 N/A N/A N/A N/A N/A N/A N/A 4.991±0.00 22.603±0.74 0.203±0.00
ENSMUST00000043637 3.379±1.10 0.931±0.12 1.218±0.33 0.107±0.02 1.494±0.37 0.595±0.06 3.056±1.24 1.709±0.14 0.228±0.10 1.375±0.34 1.132±0.65 1.384±0.60 10.051±5.38 0.157±0.01
ENSMUST00000101123 3.857±1.93 1.075±0.40 N/A 0.480±0.00 2.973±0.99 1.037±0.47 6.614±0.91 2.387±0.58 0.411±0.17 1.680±0.73 N/A 4.634±0.79 N/A 0.232±0.09
ENSMUST00000113339 N/A 0.853±0.15 N/A N/A 2.019±0.84 0.459±0.00 N/A 0.885±0.13 N/A 0.993±0.36 N/A 5.849±0.00 N/A N/A
ENSMUST00000139462 N/A N/A N/A N/A N/A N/A N/A N/A 0.278±0.03 N/A N/A N/A N/A N/A
ENSMUST00000148233 N/A 1.252±0.00 N/A N/A N/A N/A N/A N/A 0.318±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001TC CIL_0001TC_0003 CGP 6:97286867-98021349

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006461 IEA protein complex assembly
GO:0010468 IMP regulation of gene expression
GO:0016055 IDA Wnt signaling pathway
GO:0030154 IMP cell differentiation
GO:0030316 IMP osteoclast differentiation
GO:0030318 IGI melanocyte differentiation
GO:0042127 IDA regulation of cell proliferation
GO:0043010 IGI camera-type eye development
GO:0043066 IMP negative regulation of apoptotic process
GO:0043234 IEA protein complex
GO:0043473 IGI pigmentation
GO:0043565 ISA sequence-specific DNA binding
GO:0044336 IDA canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045165 IMP cell fate commitment
GO:0045670 IGI regulation of osteoclast differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046849 IMP bone remodeling
GO:0046983 IEA protein dimerization activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003732 mitfa microphthalmia-associated transcription factor a protein_coding Danio_rerio
ENSDARG00000037833 mitfb microphthalmia-associated transcription factor b protein_coding Danio_rerio
ENSG00000187098 MITF microphthalmia-associated transcription factor protein_coding Homo_sapiens

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