C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: microphthalmia-associated transcription factor
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000043637 Mitf-001 ENSMUSG00000035158 10090 + 6:97807058-98021349 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000043637
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000043637 3.379±1.10 0.931±0.12 1.218±0.33 0.107±0.02 1.494±0.37 0.595±0.06 3.056±1.24 1.709±0.14 0.228±0.10 1.375±0.34 1.132±0.65 1.384±0.60 10.051±5.38 0.157±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001TC CIL_0001TC_0003 CGP 6:97286867-98021349

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006461 IEA protein complex assembly
GO:0010468 IMP regulation of gene expression
GO:0016055 IDA Wnt signaling pathway
GO:0030154 IMP cell differentiation
GO:0030316 IMP osteoclast differentiation
GO:0030318 IGI melanocyte differentiation
GO:0042127 IDA regulation of cell proliferation
GO:0043010 IGI camera-type eye development
GO:0043066 IMP negative regulation of apoptotic process
GO:0043234 IEA protein complex
GO:0043473 IGI pigmentation
GO:0043565 ISA sequence-specific DNA binding
GO:0044336 IDA canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045165 IMP cell fate commitment
GO:0045670 IGI regulation of osteoclast differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046849 IMP bone remodeling
GO:0046983 IEA protein dimerization activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000314557 MITF-005 protein_coding Homo_sapiens 0 1742
ENST00000314589 MITF-015 protein_coding Homo_sapiens 0 2132
ENST00000328528 MITF-201 protein_coding Homo_sapiens 0 2154
ENST00000352241 MITF-001 protein_coding Homo_sapiens 0 2377
ENST00000394348 MITF-006 protein_coding Homo_sapiens 0 348
ENST00000394351 MITF-004 protein_coding Homo_sapiens 0 1853
ENST00000429090 MITF-012 protein_coding Homo_sapiens 0 442
ENST00000433517 MITF-009 protein_coding Homo_sapiens 0 501
ENST00000448226 MITF-007 protein_coding Homo_sapiens 0 2488
ENST00000451708 MITF-003 protein_coding Homo_sapiens 0 1467
ENST00000457080 MITF-002 protein_coding Homo_sapiens 0 416
ENST00000461014 MITF-013 processed_transcript Homo_sapiens 0 577
ENST00000461511 MITF-011 processed_transcript Homo_sapiens 0 224
ENST00000472437 MITF-014 protein_coding Homo_sapiens 0 2134
ENST00000478490 MITF-008 nonsense_mediated_decay Homo_sapiens 0 1332
ENST00000495741 MITF-010 processed_transcript Homo_sapiens 0 353
ENST00000531774 MITF-016 protein_coding Homo_sapiens 0 1018

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