C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: microphthalmia-associated transcription factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000187098 MITF 9606 + 3:69739435-69968337 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000314557 MITF-005 69936587-69965668 protein_coding
  ENST00000314589 MITF-015 69866212-69965647 protein_coding
  ENST00000328528 MITF-201 69763811-69968337 protein_coding
  ENST00000352241 MITF-001 69739435-69968336 protein_coding
  ENST00000394348 MITF-006 69936629-69939065 protein_coding
  ENST00000394351 MITF-004 69936603-69965824 protein_coding
  ENST00000429090 MITF-012 69758704-69937835 protein_coding
  ENST00000433517 MITF-009 69762724-69949083 protein_coding
  ENST00000448226 MITF-007 69739471-69966029 protein_coding
  ENST00000451708 MITF-003 69866259-69959373 protein_coding
  ENST00000457080 MITF-002 69763811-69879383 protein_coding
  ENST00000461014 MITF-013 69936829-69941331 processed_transcript
  ENST00000461511 MITF-011 69739474-69752385 processed_transcript
  ENST00000472437 MITF-014 69763556-69965647 protein_coding
  ENST00000478490 MITF-008 69936628-69965570 nonsense_mediated_decay
  ENST00000495741 MITF-010 69739482-69879347 processed_transcript
  ENST00000531774 MITF-016 69936723-69965248 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000314557ENST00000314589ENST00000352241ENST00000448226ENST00000472437ENST00000531774
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000314557 N/A N/A N/A N/A N/A 0.482±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000314589 N/A N/A 4.604±0.00 N/A N/A N/A 3.954±0.00 N/A N/A 1.062±0.00 N/A N/A N/A N/A
ENST00000352241 9.466±0.00 2.888±0.00 N/A 1.214±0.00 3.779±0.00 3.391±3.20 14.434±0.00 5.733±0.00 0.893±0.50 3.521±0.00 17.323±16.15 3.596±0.79 1.008±0.28 2.330±2.02
ENST00000448226 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.366±0.00 N/A N/A N/A
ENST00000472437 N/A N/A N/A N/A 2.013±0.00 N/A N/A N/A N/A N/A 2.362±0.00 N/A N/A N/A
ENST00000531774 N/A N/A 2.903±0.00 1.650±0.00 3.034±0.00 0.853±0.00 4.504±0.00 N/A 3.623±0.00 1.784±0.00 3.560±0.00 1.227±0.61 3.759±0.00 1.830±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001TC CIL_0001TC_0002 CGP 3:69169990-69968337

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001227 NAS RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 NAS nucleus
GO:0006355 NAS:IEA regulation of transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006461 IDA protein complex assembly
GO:0010468 IEA regulation of gene expression
GO:0016055 IEA Wnt signaling pathway
GO:0030154 IEA cell differentiation
GO:0030316 IEA osteoclast differentiation
GO:0030318 NAS melanocyte differentiation
GO:0042127 IEA regulation of cell proliferation
GO:0043010 IEA camera-type eye development
GO:0043066 IEA negative regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0043473 IEA pigmentation
GO:0044336 IEA canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045165 IEA cell fate commitment
GO:0045670 IEA regulation of osteoclast differentiation
GO:0045893 NAS positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046849 IEA bone remodeling
GO:0046983 IEA protein dimerization activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003732 mitfa microphthalmia-associated transcription factor a protein_coding Danio_rerio
ENSDARG00000037833 mitfb microphthalmia-associated transcription factor b protein_coding Danio_rerio
ENSMUSG00000035158 Mitf microphthalmia-associated transcription factor protein_coding Mus_musculus

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