C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: retinoic acid receptor, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000037992 Rara 10090 + 11:98927818-98974942 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000068133 Rara-001 98937718-98974942 protein_coding
  ENSMUST00000107473 Rara-004 98960412-98974942 protein_coding
  ENSMUST00000107474 Rara-003 98927818-98974162 protein_coding
  ENSMUST00000107475 Rara-002 98937698-98974162 protein_coding
  ENSMUST00000139399 Rara-005 98938328-98950361 processed_transcript
  ENSMUST00000147985 Rara-006 98939712-98950490 processed_transcript
  ENSMUST00000164748 Rara-201 98939711-98974942 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000068133ENSMUST00000107473ENSMUST00000107474ENSMUST00000107475ENSMUST00000164748
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000068133 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.319±0.00 N/A N/A N/A
ENSMUST00000107473 2.864±0.59 2.216±0.53 1.657±0.51 1.152±0.30 4.028±2.08 5.760±0.74 0.508±0.08 1.207±0.14 1.508±0.78 6.889±1.40 0.572±0.21 4.098±1.51 1.530±0.88 2.492±0.29
ENSMUST00000107474 N/A N/A N/A 1.713±0.22 N/A N/A N/A N/A 0.356±0.00 N/A N/A 3.544±0.99 1.532±0.54 1.808±0.44
ENSMUST00000107475 2.879±0.26 7.183±3.33 2.787±1.23 2.307±1.66 10.344±2.92 6.642±1.80 1.100±0.40 2.016±1.34 2.009±1.06 9.807±4.35 1.725±0.47 8.596±2.25 1.795±0.74 3.135±0.56
ENSMUST00000164748 N/A N/A N/A N/A N/A N/A N/A N/A 0.542±0.00 N/A 1.882±0.27 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00098Y CIL_00098Y_0002 VISTA 11:98447152-99051430
CIL_0002GL CIL_0002GL_0002 CGP 11:98907801-98974942
CIL_00050G CIL_00050G_0002 CGP 11:98927818-98983016

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IGI negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IEA nuclear chromatin
GO:0000900 IEA translation repressor activity, nucleic acid binding
GO:0000977 IDA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001012 IDA RNA polymerase II regulatory region DNA binding
GO:0001657 IMP ureteric bud development
GO:0001843 IGI neural tube closure
GO:0001889 IEA liver development
GO:0001972 IEA retinoic acid binding
GO:0002068 IGI glandular epithelial cell development
GO:0003148 IGI outflow tract septum morphogenesis
GO:0003417 IGI growth plate cartilage development
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0003708 IDA retinoic acid receptor activity
GO:0003713 IEA transcription coactivator activity
GO:0003714 IEA transcription corepressor activity
GO:0004879 IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0007165 IEA signal transduction
GO:0007281 IMP germ cell development
GO:0007283 IMP spermatogenesis
GO:0007565 IEA female pregnancy
GO:0008134 IPI transcription factor binding
GO:0008144 IEA drug binding
GO:0008270 IEA zinc ion binding
GO:0008284 IGI positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0008584 IEA male gonad development
GO:0010628 IMP positive regulation of gene expression
GO:0010629 IGI negative regulation of gene expression
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0017148 IEA negative regulation of translation
GO:0019899 IEA enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0030425 IDA dendrite
GO:0030520 IEA intracellular estrogen receptor signaling pathway
GO:0030850 IEA prostate gland development
GO:0030852 IMP regulation of granulocyte differentiation
GO:0030853 IEA negative regulation of granulocyte differentiation
GO:0031076 IGI embryonic camera-type eye development
GO:0031490 IEA chromatin DNA binding
GO:0031641 IEA regulation of myelination
GO:0032355 IEA response to estradiol
GO:0032526 IMP response to retinoic acid
GO:0032689 IEA negative regulation of interferon-gamma production
GO:0032720 IEA negative regulation of tumor necrosis factor production
GO:0032736 IEA positive regulation of interleukin-13 production
GO:0032753 IEA positive regulation of interleukin-4 production
GO:0032754 IEA positive regulation of interleukin-5 production
GO:0033189 IEA response to vitamin A
GO:0034097 IEA response to cytokine
GO:0035014 IEA phosphatidylinositol 3-kinase regulator activity
GO:0035264 IGI multicellular organism growth
GO:0042981 IEA regulation of apoptotic process
GO:0043005 IEA neuron projection
GO:0043025 IDA neuronal cell body
GO:0043066 IGI negative regulation of apoptotic process
GO:0043277 IEA apoptotic cell clearance
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043422 IEA protein kinase B binding
GO:0043551 IEA regulation of phosphatidylinositol 3-kinase activity
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IMP transcription regulatory region DNA binding
GO:0044323 IEA retinoic acid-responsive element binding
GO:0045471 IEA response to ethanol
GO:0045596 IMP negative regulation of cell differentiation
GO:0045630 IEA positive regulation of T-helper 2 cell differentiation
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045787 IEA positive regulation of cell cycle
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0045947 IDA negative regulation of translational initiation
GO:0046982 IEA protein heterodimerization activity
GO:0048027 IEA mRNA 5'-UTR binding
GO:0048167 IEA regulation of synaptic plasticity
GO:0048384 IEA retinoic acid receptor signaling pathway
GO:0048471 IEA perinuclear region of cytoplasm
GO:0051018 IEA protein kinase A binding
GO:0051099 IEA positive regulation of binding
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0055012 IMP ventricular cardiac muscle cell differentiation
GO:0060010 IMP Sertoli cell fate commitment
GO:0060173 IGI limb development
GO:0060324 IGI face development
GO:0060348 IGI bone development
GO:0060534 IMP trachea cartilage development
GO:0060591 IMP chondroblast differentiation
GO:0061037 IMP negative regulation of cartilage development
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0071300 IEA cellular response to retinoic acid
GO:0071391 IEA cellular response to estrogen stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000034893 rarab retinoic acid receptor, alpha b protein_coding Danio_rerio
ENSDARG00000056783 raraa retinoic acid receptor, alpha a protein_coding Danio_rerio
ENSG00000131759 RARA retinoic acid receptor, alpha protein_coding Homo_sapiens

Loading