C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: optic atrophy 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000038084 Opa1 10090 + 16:29579334-29654884 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000038867 Opa1-003 29579380-29651876 protein_coding
  ENSMUST00000159036 Opa1-004 29579378-29614624 retained_intron
  ENSMUST00000160101 Opa1-006 29616625-29618707 retained_intron
  ENSMUST00000160153 Opa1-005 29579392-29651879 retained_intron
  ENSMUST00000160475 Opa1-002 29579380-29630404 nonsense_mediated_decay
  ENSMUST00000160597 Opa1-001 29579334-29654884 protein_coding
  ENSMUST00000161186 Opa1-008 29579380-29649000 protein_coding
  ENSMUST00000162240 Opa1-007 29587014-29610906 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000038867ENSMUST00000159036ENSMUST00000160153ENSMUST00000160597ENSMUST00000161186
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000038867 N/A N/A N/A N/A N/A N/A N/A N/A 2.388±0.44 N/A 2.899±0.00 4.679±0.69 6.891±1.65 N/A
ENSMUST00000159036 N/A 10.306±2.56 N/A N/A N/A 2.768±0.70 N/A N/A 4.619±0.80 N/A N/A 4.758±1.29 N/A N/A
ENSMUST00000160153 1.618±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000160597 7.647±2.39 6.028±1.32 9.129±0.18 13.034±0.79 5.021±2.84 5.111±0.48 15.697±0.50 10.639±0.24 4.113±1.24 2.863±1.58 10.473±3.51 4.671±2.14 4.982±2.05 1.980±1.04
ENSMUST00000161186 N/A N/A N/A 17.047±0.00 N/A N/A N/A N/A 2.831±0.52 N/A N/A 7.668±4.36 5.790±3.06 6.000±5.74

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000N8 CIL_0000N8_0002 CGP 16:29395853-29654884
CIL_0008CV CIL_0008CV_0002 VISTA 16:29419360-30021162

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001843 IMP neural tube closure
GO:0003924 IEA GTPase activity
GO:0005515 IEA protein binding
GO:0005525 IEA GTP binding
GO:0005739 IDA mitochondrion
GO:0005741 IEA mitochondrial outer membrane
GO:0005743 IDA mitochondrial inner membrane
GO:0005758 IDA mitochondrial intermembrane space
GO:0006184 IEA GTP catabolic process
GO:0006915 IEA apoptotic process
GO:0007005 IDA mitochondrion organization
GO:0007007 IEA inner mitochondrial membrane organization
GO:0007601 IEA visual perception
GO:0008053 IDA mitochondrial fusion
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0030061 IEA mitochondrial crista
GO:0030425 IDA dendrite
GO:0090201 IEA negative regulation of release of cytochrome c from mitochondria
GO:0090398 IEA cellular senescence
GO:1902236 IEA negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:2001243 IMP negative regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044329 opa1 optic atrophy 1 (human) protein_coding Danio_rerio
ENSDARG00000070801 opa1 optic atrophy 1 (human) protein_coding Danio_rerio
ENSG00000198836 OPA1 optic atrophy 1 (autosomal dominant) protein_coding Homo_sapiens

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