C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: recombination signal binding protein for immunoglobulin kappa J region
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000039191 Rbpj 10090 + 5:53555779-53657445 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000037618 Rbpj-201 53590215-53657445 protein_coding
  ENSMUST00000087360 Rbpj-202 53555779-53657445 protein_coding
  ENSMUST00000113865 Rbpj-203 53590574-53657445 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000037618ENSMUST00000087360ENSMUST00000113865
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000037618 N/A N/A N/A 0.458±0.00 N/A 0.825±0.00 N/A N/A N/A N/A 0.460±0.02 N/A N/A 0.393±0.00
ENSMUST00000087360 4.617±1.19 9.704±2.65 N/A 0.695±0.00 13.418±1.39 4.755±0.98 3.413±0.00 4.229±2.65 2.066±0.90 5.857±2.19 N/A 18.970±6.05 N/A 2.560±0.00
ENSMUST00000113865 9.433±3.43 2.650±0.38 11.162±4.40 11.870±7.80 8.960±4.90 2.061±0.63 4.416±1.69 2.274±1.78 2.788±1.64 7.884±2.80 4.266±0.40 9.175±4.39 7.043±2.69 1.814±1.13

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000343 CIL_000343_0003 CGP 5:53267106-53657445
CIL_0002TR CIL_0002TR_0003 CGP 5:53555779-53707704

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077 ISO RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001103 IEA RNA polymerase II repressing transcription factor binding
GO:0001228 IDA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001525 IMP angiogenesis
GO:0001756 TAS somitogenesis
GO:0001837 IMP epithelial to mesenchymal transition
GO:0001947 TAS heart looping
GO:0001974 IMP blood vessel remodeling
GO:0002193 IEA MAML1-RBP-Jkappa- ICN1 complex
GO:0002437 IMP inflammatory response to antigenic stimulus
GO:0003139 IGI secondary heart field specification
GO:0003151 IMP outflow tract morphogenesis
GO:0003157 IMP endocardium development
GO:0003160 IMP endocardium morphogenesis
GO:0003198 IMP epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003214 IMP cardiac left ventricle morphogenesis
GO:0003222 IMP ventricular trabecula myocardium morphogenesis
GO:0003256 IMP regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003677 ISA DNA binding
GO:0003682 IDA chromatin binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0005730 IEA nucleolus
GO:0005737 ISS cytoplasm
GO:0006357 IGI regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006959 IMP humoral immune response
GO:0007219 IMP Notch signaling pathway
GO:0007221 ISS positive regulation of transcription of Notch receptor target
GO:0007507 IMP heart development
GO:0008134 IPI transcription factor binding
GO:0008284 IGI positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0009912 IMP auditory receptor cell fate commitment
GO:0009957 IMP epidermal cell fate specification
GO:0010468 IMP regulation of gene expression
GO:0010628 IMP positive regulation of gene expression
GO:0021983 IMP pituitary gland development
GO:0030097 IMP hemopoiesis
GO:0030182 IMP neuron differentiation
GO:0030183 IMP B cell differentiation
GO:0030216 IMP keratinocyte differentiation
GO:0030279 IMP negative regulation of ossification
GO:0030513 IMP positive regulation of BMP signaling pathway
GO:0035019 IMP somatic stem cell maintenance
GO:0035481 TAS positive regulation of Notch signaling pathway involved in heart induction
GO:0035912 IMP dorsal aorta morphogenesis
GO:0036302 IMP atrioventricular canal development
GO:0042742 IMP defense response to bacterium
GO:0043011 IMP myeloid dendritic cell differentiation
GO:0043565 IDA sequence-specific DNA binding
GO:0045165 IMP cell fate commitment
GO:0045596 IMP negative regulation of cell differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 ISA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0047485 IPI protein N-terminus binding
GO:0048505 IMP regulation of timing of cell differentiation
GO:0048733 IMP sebaceous gland development
GO:0048820 IMP hair follicle maturation
GO:0060045 IMP positive regulation of cardiac muscle cell proliferation
GO:0060486 IMP Clara cell differentiation
GO:0060716 IMP labyrinthine layer blood vessel development
GO:0060844 IMP arterial endothelial cell fate commitment
GO:0060853 IC Notch signaling pathway involved in arterial endothelial cell fate commitment
GO:0061344 IC regulation of cell adhesion involved in heart morphogenesis
GO:0061371 TAS determination of heart left/right asymmetry
GO:0072554 IMP blood vessel lumenization
GO:0072602 IMP interleukin-4 secretion
GO:0097101 IGI blood vessel endothelial cell fate specification
GO:1901186 IMP positive regulation of ERBB signaling pathway
GO:1901189 IMP positive regulation of ephrin receptor signaling pathway
GO:1901297 IMP positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
GO:2000138 IMP positive regulation of cell proliferation involved in heart morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052091 rbpjb recombination signal binding protein for immunoglobulin kappa J region b protein_coding Danio_rerio
ENSG00000168214 RBPJ recombination signal binding protein for immunoglobulin kappa J region protein_coding Homo_sapiens

Loading