C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: recombination signal binding protein for immunoglobulin kappa J region
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168214 RBPJ 9606 + 4:26163455-26435131 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000342295 RBPJ-201 26319710-26435128 protein_coding
  ENST00000342320 RBPJ-003 26362436-26435131 protein_coding
  ENST00000345843 RBPJ-001 26319710-26431066 protein_coding
  ENST00000348160 RBPJ-030 26320800-26431066 protein_coding
  ENST00000355476 RBPJ-202 26320807-26435128 protein_coding
  ENST00000361572 RBPJ-002 26320563-26431007 protein_coding
  ENST00000504423 RBPJ-026 26428720-26430851 protein_coding
  ENST00000504907 RBPJ-010 26362436-26431156 protein_coding
  ENST00000504938 RBPJ-020 26362530-26420725 protein_coding
  ENST00000505727 RBPJ-028 26430146-26431174 retained_intron
  ENST00000505958 RBPJ-006 26321365-26406203 protein_coding
  ENST00000506903 RBPJ-025 26420570-26424994 retained_intron
  ENST00000506956 RBPJ-011 26319662-26415613 protein_coding
  ENST00000507561 RBPJ-007 26321602-26431183 protein_coding
  ENST00000507574 RBPJ-015 26322209-26424383 protein_coding
  ENST00000509158 RBPJ-013 26320807-26406265 protein_coding
  ENST00000510725 RBPJ-027 26428613-26430195 retained_intron
  ENST00000510778 RBPJ-029 26272607-26424426 protein_coding
  ENST00000511401 RBPJ-022 26321014-26415640 processed_transcript
  ENST00000511451 RBPJ-021 26362476-26420838 retained_intron
  ENST00000511546 RBPJ-018 26359691-26420553 protein_coding
  ENST00000512351 RBPJ-004 26163455-26415605 protein_coding
  ENST00000512671 RBPJ-005 26319686-26420725 protein_coding
  ENST00000513182 RBPJ-024 26321007-26415583 nonsense_mediated_decay
  ENST00000514380 RBPJ-009 26320725-26430457 retained_intron
  ENST00000514656 RBPJ-019 26362446-26368145 processed_transcript
  ENST00000514675 RBPJ-016 26322870-26420563 protein_coding
  ENST00000514730 RBPJ-014 26322164-26420571 protein_coding
  ENST00000514807 RBPJ-012 26320787-26406263 protein_coding
  ENST00000515023 RBPJ-023 26321020-26415640 processed_transcript
  ENST00000515573 RBPJ-017 26343140-26424479 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000342295ENST00000342320ENST00000348160ENST00000355476ENST00000361572ENST00000504907ENST00000507561ENST00000511401
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000342295 N/A N/A N/A N/A N/A N/A 1.009±0.00 N/A N/A N/A N/A 2.775±0.20 2.893±0.44 9.626±0.00
ENST00000342320 N/A N/A N/A 3.462±0.00 5.931±0.00 2.034±0.00 1.357±0.24 N/A 3.078±1.67 N/A 0.982±0.67 3.163±1.77 6.729±0.23 N/A
ENST00000348160 15.649±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000355476 3.912±0.00 3.773±0.00 N/A 3.551±0.00 11.335±0.00 7.172±0.00 1.548±0.00 3.115±0.00 0.612±0.00 2.942±0.33 N/A 5.050±5.51 N/A 2.593±0.00
ENST00000361572 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.084±0.00
ENST00000504907 N/A N/A N/A N/A N/A N/A 1.263±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000507561 N/A 14.205±0.00 2.841±0.00 8.746±0.00 11.632±2.15 6.247±0.00 1.967±0.00 4.849±0.00 15.277±0.00 7.844±0.00 3.378±0.00 6.768±0.00 N/A 13.509±0.00
ENST00000511401 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.706±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000343 CIL_000343_0002 CGP 4:25861830-26435131
CIL_0002TR CIL_0002TR_0002 CGP 4:26163455-26490462

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000150 NAS recombinase activity
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001103 IPI RNA polymerase II repressing transcription factor binding
GO:0001228 IEA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001525 ISS angiogenesis
GO:0001837 ISS epithelial to mesenchymal transition
GO:0001974 IEA blood vessel remodeling
GO:0002193 IDA MAML1-RBP-Jkappa- ICN1 complex
GO:0002437 IEA inflammatory response to antigenic stimulus
GO:0003139 IEA secondary heart field specification
GO:0003151 ISS outflow tract morphogenesis
GO:0003157 IEA endocardium development
GO:0003160 ISS endocardium morphogenesis
GO:0003198 ISS epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003214 ISS cardiac left ventricle morphogenesis
GO:0003222 ISS ventricular trabecula myocardium morphogenesis
GO:0003256 ISS regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003677 TAS:IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 TAS:IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IEA:IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0006310 NAS DNA recombination
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006959 IEA humoral immune response
GO:0007219 IMP Notch signaling pathway
GO:0007221 IDA positive regulation of transcription of Notch receptor target
GO:0007507 IEA heart development
GO:0008134 IEA transcription factor binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0009912 IEA auditory receptor cell fate commitment
GO:0009957 IEA epidermal cell fate specification
GO:0010467 TAS gene expression
GO:0010468 IEA regulation of gene expression
GO:0010628 IEA positive regulation of gene expression
GO:0021983 IEA pituitary gland development
GO:0030097 IEA hemopoiesis
GO:0030182 IEA neuron differentiation
GO:0030183 IEA B cell differentiation
GO:0030216 IEA keratinocyte differentiation
GO:0030279 ISS negative regulation of ossification
GO:0030513 ISS positive regulation of BMP signaling pathway
GO:0035019 IEA somatic stem cell maintenance
GO:0035912 ISS dorsal aorta morphogenesis
GO:0036302 ISS atrioventricular canal development
GO:0042742 IEA defense response to bacterium
GO:0043011 IEA myeloid dendritic cell differentiation
GO:0043565 IEA sequence-specific DNA binding
GO:0045165 IEA cell fate commitment
GO:0045596 IEA negative regulation of cell differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0047485 IEA protein N-terminus binding
GO:0048505 IEA regulation of timing of cell differentiation
GO:0048733 IEA sebaceous gland development
GO:0048820 IEA hair follicle maturation
GO:0060045 ISS positive regulation of cardiac muscle cell proliferation
GO:0060486 IEA Clara cell differentiation
GO:0060716 ISS labyrinthine layer blood vessel development
GO:0060844 IEA arterial endothelial cell fate commitment
GO:0061314 IC Notch signaling involved in heart development
GO:0072554 ISS blood vessel lumenization
GO:0072602 IEA interleukin-4 secretion
GO:0097101 ISS blood vessel endothelial cell fate specification
GO:1901186 ISS positive regulation of ERBB signaling pathway
GO:1901189 ISS positive regulation of ephrin receptor signaling pathway
GO:1901297 IEA positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
GO:2000138 ISS positive regulation of cell proliferation involved in heart morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052091 rbpjb recombination signal binding protein for immunoglobulin kappa J region b protein_coding Danio_rerio
ENSMUSG00000039191 Rbpj recombination signal binding protein for immunoglobulin kappa J region protein_coding Mus_musculus

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