C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rap guanine nucleotide exchange factor (GEF) 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000039844 Rapgef1 10090 + 2:29619720-29740978 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000091146 Rapgef1-004 29619741-29740363 protein_coding
  ENSMUST00000095087 Rapgef1-007 29619720-29740353 protein_coding
  ENSMUST00000102872 Rapgef1-001 29619770-29740978 protein_coding
  ENSMUST00000123953 Rapgef1-006 29732561-29734225 retained_intron
  ENSMUST00000137719 Rapgef1-005 29730593-29735848 processed_transcript
  ENSMUST00000147488 Rapgef1-002 29702482-29740363 protein_coding
  ENSMUST00000147755 Rapgef1-003 29619910-29738327 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000091146ENSMUST00000095087ENSMUST00000102872ENSMUST00000147488ENSMUST00000147755
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000091146 N/A N/A N/A N/A 6.934±0.82 N/A 2.918±0.59 N/A 1.118±0.12 4.996±0.00 24.808±2.18 N/A N/A N/A
ENSMUST00000095087 N/A N/A 2.915±0.00 12.907±1.48 N/A N/A 9.800±1.80 N/A N/A N/A 15.772±2.45 8.265±0.00 16.900±0.96 5.553±2.24
ENSMUST00000102872 13.696±5.72 19.218±3.12 1.981±0.00 2.960±0.00 22.585±11.53 16.091±1.72 3.676±0.32 7.070±2.95 5.824±3.43 19.940±4.20 N/A 18.752±8.69 12.506±11.14 2.567±0.15
ENSMUST00000147488 10.720±4.12 4.036±0.05 3.488±0.16 7.137±0.46 14.397±5.31 7.342±0.00 4.071±0.00 4.451±0.00 2.362±0.64 N/A N/A 7.225±2.03 15.628±6.06 5.286±0.68
ENSMUST00000147755 N/A 4.955±0.87 N/A 12.874±3.47 7.427±0.00 N/A 5.884±1.28 N/A N/A N/A 8.036±0.00 8.968±0.00 23.574±1.60 7.812±1.71

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001568 IMP blood vessel development
GO:0004871 TAS signal transducer activity
GO:0005070 TAS SH3/SH2 adaptor activity
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005515 IEA protein binding
GO:0005622 IEA intracellular
GO:0005769 IEA early endosome
GO:0007264 IEA small GTPase mediated signal transduction
GO:0009967 TAS positive regulation of signal transduction
GO:0010976 IEA positive regulation of neuron projection development
GO:0016337 IMP single organismal cell-cell adhesion
GO:0017034 IEA Rap guanyl-nucleotide exchange factor activity
GO:0032486 IEA Rap protein signal transduction
GO:0032854 IEA positive regulation of Rap GTPase activity
GO:0038180 IEA nerve growth factor signaling pathway
GO:0043547 IEA positive regulation of GTPase activity
GO:0046580 IMP negative regulation of Ras protein signal transduction
GO:0048008 IMP platelet-derived growth factor receptor signaling pathway
GO:0051898 IGI negative regulation of protein kinase B signaling
GO:0061028 IEA establishment of endothelial barrier
GO:0070373 IGI negative regulation of ERK1 and ERK2 cascade
GO:0071320 IEA cellular response to cAMP
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway
GO:1901888 IEA regulation of cell junction assembly
GO:1990090 IEA cellular response to nerve growth factor stimulus
GO:2000178 IMP negative regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015971 rapgef1b Rap guanine nucleotide exchange factor (GEF) 1b protein_coding Danio_rerio
ENSDARG00000043593 rapgef1a Rap guanine nucleotide exchange factor (GEF) 1a protein_coding Danio_rerio
ENSG00000107263 RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 protein_coding Homo_sapiens

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