C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rap guanine nucleotide exchange factor (GEF) 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000095087 Rapgef1-007 ENSMUSG00000039844 10090 + 2:29619720-29740353 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainHeartMuscleOvaryPlacentaTestisENSMUST00000095087
Transcript ID Bladder Brain Heart Muscle Ovary Placenta Testis
ENSMUST00000095087 2.915±0.00 12.907±1.48 9.800±1.80 15.772±2.45 8.265±0.00 16.900±0.96 5.553±2.24

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001568 IMP blood vessel development
GO:0004871 TAS signal transducer activity
GO:0005070 TAS SH3/SH2 adaptor activity
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005515 IEA protein binding
GO:0005769 IEA early endosome
GO:0009967 TAS positive regulation of signal transduction
GO:0010976 IEA positive regulation of neuron projection development
GO:0016337 IMP single organismal cell-cell adhesion
GO:0017034 IEA Rap guanyl-nucleotide exchange factor activity
GO:0032486 IEA Rap protein signal transduction
GO:0032854 IEA positive regulation of Rap GTPase activity
GO:0038180 IEA nerve growth factor signaling pathway
GO:0046580 IMP negative regulation of Ras protein signal transduction
GO:0048008 IMP platelet-derived growth factor receptor signaling pathway
GO:0051898 IGI negative regulation of protein kinase B signaling
GO:0061028 IEA establishment of endothelial barrier
GO:0070373 IGI negative regulation of ERK1 and ERK2 cascade
GO:0071320 IEA cellular response to cAMP
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway
GO:1901888 IEA regulation of cell junction assembly
GO:1990090 IEA cellular response to nerve growth factor stimulus
GO:2000178 IMP negative regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000064017 rapgef1a-201 protein_coding Danio_rerio 0.00000000000001 88
ENSDART00000139947 rapgef1a-001 protein_coding Danio_rerio 0.00000000000001 88
ENST00000372189 RAPGEF1-001 protein_coding Homo_sapiens 0 2045
ENST00000372190 RAPGEF1-201 protein_coding Homo_sapiens 0 2043
ENST00000372195 RAPGEF1-002 protein_coding Homo_sapiens 0 2302
ENST00000414781 RAPGEF1-006 protein_coding Homo_sapiens 0 920
ENST00000419442 RAPGEF1-007 protein_coding Homo_sapiens 0 881
ENST00000427994 RAPGEF1-004 protein_coding Homo_sapiens 0 756
ENST00000438647 RAPGEF1-003 protein_coding Homo_sapiens 0 401
ENST00000481260 RAPGEF1-008 processed_transcript Homo_sapiens 0 649

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