C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rap guanine nucleotide exchange factor (GEF) 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000107263 RAPGEF1 9606 - 9:131576770-131740074 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000372189 RAPGEF1-001 131576770-131737538 protein_coding
  ENST00000372190 RAPGEF1-201 131576771-131709842 protein_coding
  ENST00000372195 RAPGEF1-002 131576770-131740074 protein_coding
  ENST00000414781 RAPGEF1-006 131587736-131621838 protein_coding
  ENST00000419442 RAPGEF1-007 131602114-131625948 protein_coding
  ENST00000427994 RAPGEF1-004 131638709-131709842 protein_coding
  ENST00000438647 RAPGEF1-003 131638698-131739944 protein_coding
  ENST00000481260 RAPGEF1-008 131626160-131643391 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverOvaryPlacentaTestisENST00000372190ENST00000372195ENST00000427994ENST00000481260
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Ovary Placenta Testis
ENST00000372190 14.361±0.00 6.848±0.00 0.827±0.00 0.629±0.00 6.715±0.00 2.084±0.00 1.232±0.00 1.379±0.00 0.947±0.00 3.179±1.40 15.627±6.95 2.671±0.00
ENST00000372195 14.084±0.00 19.321±0.00 N/A 5.266±0.00 14.636±0.00 4.253±3.52 3.855±3.30 10.775±0.00 5.607±0.00 5.132±3.40 11.285±0.54 N/A
ENST00000427994 N/A N/A N/A N/A N/A N/A 2.677±0.00 N/A N/A N/A N/A N/A
ENST00000481260 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 11.361±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00088E CIL_00088E_0001 VISTA 9:131030990-131632063
CIL_0002EB CIL_0002EB_0002 CGP 9:131576770-132079908

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000186 TAS activation of MAPKK activity
GO:0001568 IEA blood vessel development
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005768 TAS endosome
GO:0005769 IDA early endosome
GO:0005829 TAS cytosol
GO:0007165 NAS signal transduction
GO:0007169 TAS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007264 IEA small GTPase mediated signal transduction
GO:0010976 IMP positive regulation of neuron projection development
GO:0016337 IEA single organismal cell-cell adhesion
GO:0017034 IDA Rap guanyl-nucleotide exchange factor activity
GO:0017124 IEA SH3 domain binding
GO:0032486 IMP Rap protein signal transduction
GO:0032854 IDA positive regulation of Rap GTPase activity
GO:0038180 IDA nerve growth factor signaling pathway
GO:0043547 IEA positive regulation of GTPase activity
GO:0046580 IEA negative regulation of Ras protein signal transduction
GO:0048008 IEA platelet-derived growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 IEA regulation of small GTPase mediated signal transduction
GO:0051898 IEA negative regulation of protein kinase B signaling
GO:0061028 IMP establishment of endothelial barrier
GO:0070373 IEA negative regulation of ERK1 and ERK2 cascade
GO:0071320 IDA cellular response to cAMP
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:1901888 IMP regulation of cell junction assembly
GO:1990090 IDA cellular response to nerve growth factor stimulus
GO:2000178 IEA negative regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015971 rapgef1b Rap guanine nucleotide exchange factor (GEF) 1b protein_coding Danio_rerio
ENSDARG00000043593 rapgef1a Rap guanine nucleotide exchange factor (GEF) 1a protein_coding Danio_rerio
ENSMUSG00000039844 Rapgef1 Rap guanine nucleotide exchange factor (GEF) 1 protein_coding Mus_musculus

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