C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rap guanine nucleotide exchange factor (GEF) 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000102872 Rapgef1-001 ENSMUSG00000039844 10090 + 2:29619770-29740978 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000102872
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000102872 13.696±5.72 19.218±3.12 1.981±0.00 2.960±0.00 22.585±11.53 16.091±1.72 3.676±0.32 7.070±2.95 5.824±3.43 19.940±4.20 18.752±8.69 12.506±11.14 2.567±0.15

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001568 IMP blood vessel development
GO:0004871 TAS signal transducer activity
GO:0005070 TAS SH3/SH2 adaptor activity
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0007264 IEA small GTPase mediated signal transduction
GO:0009967 TAS positive regulation of signal transduction
GO:0016337 IMP single organismal cell-cell adhesion
GO:0043547 IEA positive regulation of GTPase activity
GO:0046580 IMP negative regulation of Ras protein signal transduction
GO:0048008 IMP platelet-derived growth factor receptor signaling pathway
GO:0051898 IGI negative regulation of protein kinase B signaling
GO:0070373 IGI negative regulation of ERK1 and ERK2 cascade
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway
GO:2000178 IMP negative regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000064017 rapgef1a-201 protein_coding Danio_rerio 0.00000000000001 88
ENSDART00000139947 rapgef1a-001 protein_coding Danio_rerio 0.00000000000001 88
ENST00000372189 RAPGEF1-001 protein_coding Homo_sapiens 0 3655
ENST00000372190 RAPGEF1-201 protein_coding Homo_sapiens 0 3653
ENST00000372195 RAPGEF1-002 protein_coding Homo_sapiens 0 3908
ENST00000414781 RAPGEF1-006 protein_coding Homo_sapiens 0 920
ENST00000427994 RAPGEF1-004 protein_coding Homo_sapiens 0 756
ENST00000438647 RAPGEF1-003 protein_coding Homo_sapiens 0 401
ENST00000481260 RAPGEF1-008 processed_transcript Homo_sapiens 0 649

Loading