C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: WNK lysine deficient protein kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000045962 Wnk1 10090 - 6:119923969-120038672 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000035513 Wnk1-006 119969565-119981448 processed_transcript
  ENSMUST00000060043 Wnk1-001 119923969-120038672 protein_coding
  ENSMUST00000088644 Wnk1-201 119923971-120038655 protein_coding
  ENSMUST00000088646 Wnk1-202 119923971-120038655 protein_coding
  ENSMUST00000159151 Wnk1-007 119970747-119973064 retained_intron
  ENSMUST00000159397 Wnk1-005 119953650-120038607 retained_intron
  ENSMUST00000159785 Wnk1-009 119951658-119956170 protein_coding
  ENSMUST00000159903 Wnk1-002 119923969-119927261 retained_intron
  ENSMUST00000160493 Wnk1-019 119926579-119936449 protein_coding
  ENSMUST00000160686 Wnk1-008 119956096-119962930 protein_coding
  ENSMUST00000160769 Wnk1-003 119953650-119990126 retained_intron
  ENSMUST00000160820 Wnk1-012 119937735-119940101 retained_intron
  ENSMUST00000160872 Wnk1-014 119929833-119934329 protein_coding
  ENSMUST00000161048 Wnk1-004 119952869-119990167 protein_coding
  ENSMUST00000161185 Wnk1-011 119950323-119951998 retained_intron
  ENSMUST00000161243 Wnk1-015 119927125-119937649 protein_coding
  ENSMUST00000161392 Wnk1-018 119969554-119992529 processed_transcript
  ENSMUST00000161512 Wnk1-020 119962308-119963733 protein_coding
  ENSMUST00000161802 Wnk1-016 119937615-119948105 nonsense_mediated_decay
  ENSMUST00000162190 Wnk1-013 119929833-119934328 protein_coding
  ENSMUST00000162368 Wnk1-010 119951651-119968663 protein_coding
  ENSMUST00000162541 Wnk1-017 119937460-119948426 protein_coding
  ENSMUST00000177761 Wnk1-203 119923971-120038655 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000060043ENSMUST00000088646ENSMUST00000159903ENSMUST00000161243ENSMUST00000177761
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000060043 N/A N/A N/A 7.963±1.55 9.405±3.88 N/A 17.979±3.69 N/A 2.815±1.25 N/A 9.211±3.19 N/A 7.381±4.86 19.472±7.79
ENSMUST00000088646 7.209±0.00 8.491±0.18 4.340±0.00 3.687±0.00 22.932±0.74 6.464±3.25 9.426±1.60 12.105±0.13 3.563±2.17 16.856±3.25 N/A 11.749±4.53 13.770±7.62 N/A
ENSMUST00000159903 N/A N/A 23.866±3.48 12.876±2.11 N/A N/A N/A 36.684±8.86 10.675±3.42 N/A 21.501±4.25 29.424±9.43 28.457±13.95 52.170±0.00
ENSMUST00000161243 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 106.857±0.55 N/A
ENSMUST00000177761 N/A N/A N/A 2.574±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007TY CIL_0007TY_0002 VISTA 6:119665436-120266145
CIL_0008AW CIL_0008AW_0002 VISTA 6:119874234-120475208
CIL_0006C0 CIL_0006C0_0002 CGP 6:119902698-120038672
CIL_0006BZ CIL_0006BZ_0002 CGP 6:119923969-120200339

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003084 IMP positive regulation of systemic arterial blood pressure
GO:0004672 IDA protein kinase activity
GO:0004860 IEA protein kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0006468 IDA protein phosphorylation
GO:0006469 IEA negative regulation of protein kinase activity
GO:0006811 IDA ion transport
GO:0010923 ISS negative regulation of phosphatase activity
GO:0019902 ISS phosphatase binding
GO:0050794 IDA regulation of cellular process
GO:0090188 IMP negative regulation of pancreatic juice secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000039392 wnk1b WNK lysine deficient protein kinase 1b protein_coding Danio_rerio
ENSDARG00000078992 wnk1a WNK lysine deficient protein kinase 1a protein_coding Danio_rerio
ENSDARG00000089506 WNK2 WNK lysine deficient protein kinase 1 protein_coding Danio_rerio
ENSG00000060237 WNK1 WNK lysine deficient protein kinase 1 protein_coding Homo_sapiens

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