C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cholinergic receptor, muscarinic 3, cardiac
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000046159 Chrm3 10090 - 13:9875486-10360844 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000063093 Chrm3-201 9877229-9878998 protein_coding
  ENSMUST00000187510 Chrm3-001 9875486-10360844 protein_coding
  ENSMUST00000190395 Chrm3-002 10215694-10360563 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000063093ENSMUST00000187510ENSMUST00000190395
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000063093 0.359±0.27 0.543±0.03 N/A 3.388±2.26 0.307±0.20 0.869±0.00 0.174±0.05 0.773±0.20 0.036±0.02 0.431±0.22 0.023±0.01 0.273±0.12 0.062±0.02 0.166±0.11
ENSMUST00000187510 0.481±0.30 0.938±0.38 9.844±1.06 2.336±1.73 0.240±0.17 1.146±0.42 0.185±0.08 1.168±0.10 0.016±0.01 0.974±0.28 0.052±0.03 0.461±0.22 0.076±0.05 0.069±0.04
ENSMUST00000190395 1.807±0.00 1.416±0.01 N/A N/A N/A 1.296±0.24 N/A 1.699±0.00 0.067±0.00 N/A N/A 1.375±0.70 0.155±0.00 0.303±0.16

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000LI CIL_0000LI_0002 CGP 13:9875486-12106945

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003056 IEA regulation of vascular smooth muscle contraction
GO:0005085 TAS guanyl-nucleotide exchange factor activity
GO:0005515 IEA protein binding
GO:0005886 TAS plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0006939 IMP smooth muscle contraction
GO:0007207 TAS phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
GO:0007213 ISS G-protein coupled acetylcholine receptor signaling pathway
GO:0007271 TAS synaptic transmission, cholinergic
GO:0007586 IMP digestion
GO:0008144 IEA drug binding
GO:0015464 TAS acetylcholine receptor activity
GO:0016907 ISS G-protein coupled acetylcholine receptor activity
GO:0019229 IEA regulation of vasoconstriction
GO:0030054 IEA cell junction
GO:0030425 IEA dendrite
GO:0032279 IEA asymmetric synapse
GO:0042166 ISS acetylcholine binding
GO:0043547 TAS positive regulation of GTPase activity
GO:0043679 IEA axon terminus
GO:0045211 IEA postsynaptic membrane
GO:0045987 IDA positive regulation of smooth muscle contraction
GO:0046541 IEA saliva secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000071091 chrm3a cholinergic receptor, muscarinic 3a protein_coding Danio_rerio
ENSDARG00000071298 chrm3b cholinergic receptor, muscarinic 3b protein_coding Danio_rerio
ENSG00000133019 CHRM3 cholinergic receptor, muscarinic 3 protein_coding Homo_sapiens

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