C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: forkhead box O3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000048756 Foxo3 10090 - 10:42181841-42276755 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000056974 Foxo3-002 42185786-42276742 protein_coding
  ENSMUST00000105501 Foxo3-003 42247431-42276755 protein_coding
  ENSMUST00000105502 Foxo3-001 42181841-42276752 protein_coding
  ENSMUST00000175881 Foxo3-004 42196268-42276696 protein_coding
  ENSMUST00000177542 Foxo3-005 42197554-42258366 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000056974ENSMUST00000105502ENSMUST00000175881
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000056974 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.291±0.59
ENSMUST00000105502 9.198±3.94 13.244±0.82 6.676±0.78 4.042±0.46 8.831±3.13 24.677±0.93 5.462±0.67 6.960±1.59 6.651±2.84 18.854±3.37 2.550±0.51 14.622±4.27 3.184±1.90 1.295±0.00
ENSMUST00000175881 N/A 9.623±3.02 N/A N/A 8.351±1.34 N/A N/A 4.615±0.00 2.916±0.05 N/A N/A 11.926±5.40 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00034X CIL_00034X_0002 CGP 10:41914990-42276755
CIL_0008YH CIL_0008YH_0002 VISTA 10:41950904-42552282

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IGI negative regulation of transcription from RNA polymerase II promoter
GO:0001047 IDA core promoter binding
GO:0001221 IEA transcription cofactor binding
GO:0001227 IGI RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001542 IMP ovulation from ovarian follicle
GO:0001544 IMP initiation of primordial ovarian follicle growth
GO:0001547 IMP antral ovarian follicle growth
GO:0001556 IMP oocyte maturation
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006417 ISS regulation of translation
GO:0016020 IDA membrane
GO:0019901 IEA protein kinase binding
GO:0030330 IDA DNA damage response, signal transduction by p53 class mediator
GO:0031490 IDA chromatin DNA binding
GO:0034599 IDA cellular response to oxidative stress
GO:0042593 IMP glucose homeostasis
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0045648 IEA positive regulation of erythrocyte differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway
GO:0097150 IGI neuronal stem cell maintenance
GO:0097192 IGI extrinsic apoptotic signaling pathway in absence of ligand
GO:2000177 IGI regulation of neural precursor cell proliferation
GO:2000377 IGI regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000023058 foxo3a forkhead box O3A protein_coding Danio_rerio
ENSDARG00000042904 foxo3b forkhead box O3b protein_coding Danio_rerio
ENSG00000118689 FOXO3 forkhead box O3 protein_coding Homo_sapiens

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