C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: forkhead box O3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000118689 FOXO3 9606 + 6:108559835-108684774 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000343882 FOXO3-001 108559835-108684774 protein_coding
  ENST00000406360 FOXO3-201 108560866-108684768 protein_coding
  ENST00000540898 FOXO3-202 108656346-108680751 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000343882ENST00000406360
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000343882 12.795±0.00 1.866±0.00 9.585±4.92 7.668±2.91 2.963±2.31 5.964±4.79 5.795±3.51 3.598±0.69 11.118±6.06 14.902±8.56 5.492±2.47 2.081±0.79 6.016±3.94
ENST00000406360 3.813±0.00 N/A N/A N/A 2.483±0.00 2.611±0.00 N/A 2.478±0.00 2.712±0.31 7.316±0.00 3.857±1.63 2.028±0.09 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008YH CIL_0008YH_0001 VISTA 6:108288605-108890079
CIL_0001OT CIL_0001OT_0002 CGP 6:108294894-108684774

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001047 ISS core promoter binding
GO:0001221 IEA transcription cofactor binding
GO:0001227 IEA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001542 IEA ovulation from ovarian follicle
GO:0001544 IEA initiation of primordial ovarian follicle growth
GO:0001547 IEA antral ovarian follicle growth
GO:0001556 IEA oocyte maturation
GO:0003677 IDA DNA binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 ISS regulation of transcription from RNA polymerase II promoter
GO:0006417 IDA regulation of translation
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0016020 IEA membrane
GO:0019901 IPI protein kinase binding
GO:0030330 IEA DNA damage response, signal transduction by p53 class mediator
GO:0031490 ISS chromatin DNA binding
GO:0034599 ISS cellular response to oxidative stress
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042593 IEA glucose homeostasis
GO:0043525 IMP positive regulation of neuron apoptotic process
GO:0043565 IDA:IEA sequence-specific DNA binding
GO:0045087 TAS innate immune response
GO:0045648 IDA positive regulation of erythrocyte differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:0097150 IEA neuronal stem cell maintenance
GO:0097192 IEA extrinsic apoptotic signaling pathway in absence of ligand
GO:2000177 IEA regulation of neural precursor cell proliferation
GO:2000377 IEA regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000023058 foxo3a forkhead box O3A protein_coding Danio_rerio
ENSDARG00000042904 foxo3b forkhead box O3b protein_coding Danio_rerio
ENSMUSG00000048756 Foxo3 forkhead box O3 protein_coding Mus_musculus

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