C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000048960 Prex2 10090 + 1:10993465-11303681 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027056 Prex2-001 10993465-11303681 protein_coding
  ENSMUST00000187694 Prex2-004 11140691-11160596 retained_intron
  ENSMUST00000187745 Prex2-008 11258106-11298005 nonsense_mediated_decay
  ENSMUST00000188154 Prex2-006 11283993-11298204 nonsense_mediated_decay
  ENSMUST00000188189 Prex2-007 11258067-11297898 nonsense_mediated_decay
  ENSMUST00000189385 Prex2-005 11263963-11299594 nonsense_mediated_decay
  ENSMUST00000189822 Prex2-003 11098530-11150071 retained_intron
  ENSMUST00000190935 Prex2-002 10993518-10996601 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027056ENSMUST00000187694ENSMUST00000188189ENSMUST00000189822
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027056 4.083±1.18 0.912±0.39 3.547±0.28 1.001±0.68 2.085±0.26 0.839±0.21 2.089±0.62 1.742±0.48 0.372±0.12 23.845±1.81 0.259±0.06 0.835±0.28 2.331±1.14 0.079±0.03
ENSMUST00000187694 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.028±0.00
ENSMUST00000188189 N/A 3.733±0.20 N/A N/A 4.221±0.50 2.524±0.00 N/A 3.751±0.58 1.397±0.30 N/A N/A 4.602±1.18 N/A 0.836±0.28
ENSMUST00000189822 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.182±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005BU CIL_0005BU_0003 CGP 1:10324720-11303681
CIL_00087Z CIL_00087Z_0002 VISTA 1:10726040-11328544
CIL_0001SD CIL_0001SD_0003 CGP 1:10993465-11975901

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005886 IDA plasma membrane
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0008344 IMP adult locomotory behavior
GO:0014065 IMP phosphatidylinositol 3-kinase signaling
GO:0030675 IEA Rac GTPase activator activity
GO:0030676 IEA Rac guanyl-nucleotide exchange factor activity
GO:0032855 IEA positive regulation of Rac GTPase activity
GO:0048813 IMP dendrite morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000071692 PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 protein_coding Danio_rerio
ENSG00000046889 PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 protein_coding Homo_sapiens

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