C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neurotrophin 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000049107 Ntf3 10090 - 6:126101413-126166744 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000050484 Ntf3-201 126101413-126166744 protein_coding
  ENSMUST00000112244 Ntf3-202 126101413-126166744 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000050484ENSMUST00000112244
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000050484 N/A 0.244±0.00 0.855±0.00 0.698±0.00 0.598±0.35 0.658±0.00 0.195±0.00 N/A 0.159±0.15 0.327±0.11 0.356±0.09 0.525±0.34 0.144±0.10 0.196±0.07
ENSMUST00000112244 0.599±0.04 0.446±0.17 5.098±3.16 0.221±0.00 0.534±0.16 N/A 0.395±0.20 1.682±0.00 0.071±0.03 0.893±0.08 0.671±0.13 1.057±0.32 0.184±0.09 0.216±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006C3 CIL_0006C3_0002 CGP 6:125690419-126166744

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0002092 IEA positive regulation of receptor internalization
GO:0005166 TAS neurotrophin p75 receptor binding
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005788 TAS endoplasmic reticulum lumen
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007274 IDA neuromuscular synaptic transmission
GO:0007399 IEA nervous system development
GO:0007403 IMP glial cell fate determination
GO:0007411 IDA axon guidance
GO:0007420 IMP brain development
GO:0007422 IMP peripheral nervous system development
GO:0008083 IEA growth factor activity
GO:0008284 IEA positive regulation of cell proliferation
GO:0008544 IMP epidermis development
GO:0016023 IDA cytoplasmic membrane-bounded vesicle
GO:0021675 IMP nerve development
GO:0030335 IEA positive regulation of cell migration
GO:0032148 IEA activation of protein kinase B activity
GO:0032856 IEA activation of Ras GTPase activity
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0042056 IEA chemoattractant activity
GO:0042490 IGI mechanoreceptor differentiation
GO:0042552 IEA myelination
GO:0043523 IDA regulation of neuron apoptotic process
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0045687 IEA positive regulation of glial cell differentiation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048406 IEA nerve growth factor binding
GO:0048484 IMP enteric nervous system development
GO:0048666 IMP neuron development
GO:0048699 IGI generation of neurons
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732 IEA negative regulation of peptidyl-tyrosine phosphorylation
GO:0050804 IEA regulation of synaptic transmission
GO:0050918 IEA positive chemotaxis
GO:0050930 IEA induction of positive chemotaxis
GO:0051145 IMP smooth muscle cell differentiation
GO:2000251 IEA positive regulation of actin cytoskeleton reorganization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059043 ntf3 neurotrophin 3 protein_coding Danio_rerio
ENSG00000185652 NTF3 neurotrophin 3 protein_coding Homo_sapiens

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