C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein kinase C, beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000052889 Prkcb 10090 + 7:122288751-122634402 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000064921 Prkcb-003 122289309-122634402 protein_coding
  ENSMUST00000064989 Prkcb-001 122289297-122628655 protein_coding
  ENSMUST00000127910 Prkcb-006 122599982-122628078 processed_transcript
  ENSMUST00000131167 Prkcb-004 122290028-122425041 processed_transcript
  ENSMUST00000143692 Prkcb-002 122288751-122634399 nonsense_mediated_decay
  ENSMUST00000149583 Prkcb-005 122416068-122457326 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000064921ENSMUST00000064989ENSMUST00000127910ENSMUST00000143692
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000064921 N/A 1.204±0.50 24.328±4.82 8.181±1.29 4.686±0.00 N/A 0.347±0.14 0.455±0.13 0.665±0.68 1.077±0.00 0.183±0.25 1.239±0.69 0.256±0.19 0.407±0.26
ENSMUST00000064989 2.172±0.99 1.205±0.30 N/A 70.304±0.00 9.569±3.30 0.860±0.37 0.531±0.17 0.704±0.24 0.322±0.22 2.621±0.39 0.023±0.01 1.425±0.23 0.189±0.25 1.000±0.14
ENSMUST00000127910 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.111±0.03 N/A
ENSMUST00000143692 0.840±0.00 0.773±0.35 N/A N/A 5.446±0.52 1.253±0.38 0.121±0.00 0.118±0.07 0.159±0.07 0.552±0.11 N/A 1.846±0.26 0.086±0.00 0.175±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006CY CIL_0006CY_0002 CGP 7:122219496-122634402
CIL_0003VA CIL_0003VA_0003 CGP 7:122288751-122769393

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003682 ISS chromatin binding
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004697 IDA protein kinase C activity
GO:0005080 IEA protein kinase C binding
GO:0005246 IDA calcium channel regulator activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005737 IDA cytoplasm
GO:0005886 IEA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006357 ISS regulation of transcription from RNA polymerase II promoter
GO:0006468 IDA protein phosphorylation
GO:0006816 IDA calcium ion transport
GO:0006874 IDA cellular calcium ion homeostasis
GO:0006915 IEA apoptotic process
GO:0008270 IEA zinc ion binding
GO:0010829 IMP negative regulation of glucose transport
GO:0030374 ISS ligand-dependent nuclear receptor transcription coactivator activity
GO:0030949 IMP positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035403 ISS histone kinase activity (H3-T6 specific)
GO:0035408 ISS histone H3-T6 phosphorylation
GO:0035556 IEA intracellular signal transduction
GO:0042113 IMP B cell activation
GO:0042393 ISS histone binding
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045766 IMP positive regulation of angiogenesis
GO:0046627 ISS negative regulation of insulin receptor signaling pathway
GO:0050681 ISS androgen receptor binding
GO:0050853 IMP B cell receptor signaling pathway
GO:0050861 IMP positive regulation of B cell receptor signaling pathway
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0070062 IEA extracellular vesicular exosome
GO:0071322 IDA cellular response to carbohydrate stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008723 prkcba protein kinase C, beta a protein_coding Danio_rerio
ENSDARG00000022254 prkcbb protein kinase C, beta b protein_coding Danio_rerio
ENSG00000166501 PRKCB protein kinase C, beta protein_coding Homo_sapiens

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