C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nucleotide-binding oligomerization domain containing 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000055994 Nod2 10090 + 8:88647315-88688474 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000054324 Nod2-003 88647315-88688474 protein_coding
  ENSMUST00000109634 Nod2-002 88651341-88688474 protein_coding
  ENSMUST00000118370 Nod2-001 88647315-88688474 protein_coding
  ENSMUST00000124091 Nod2-004 88647384-88665700 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000054324ENSMUST00000109634ENSMUST00000118370ENSMUST00000124091
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000054324 N/A N/A N/A N/A 0.268±0.00 N/A N/A 0.170±0.11 N/A N/A N/A N/A N/A N/A
ENSMUST00000109634 0.431±0.27 0.217±0.09 N/A 0.259±0.00 0.412±0.15 0.201±0.00 0.193±0.03 0.230±0.10 0.041±0.03 0.516±0.00 N/A 0.252±0.08 0.764±0.11 0.064±0.03
ENSMUST00000118370 0.322±0.11 N/A 0.147±0.02 0.056±0.00 0.454±0.20 0.633±0.16 0.343±0.08 0.248±0.12 0.023±0.01 0.660±0.23 0.243±0.07 0.326±0.16 0.282±0.23 0.093±0.00
ENSMUST00000124091 0.316±0.01 0.380±0.16 0.084±0.00 0.053±0.00 0.720±0.20 0.533±0.19 0.159±0.02 0.294±0.09 0.023±0.01 1.134±0.34 N/A 0.441±0.26 0.091±0.00 0.112±0.04

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007ON CIL_0007ON_0003 UCNEbase 8:88447800-92743752
CIL_00090I CIL_00090I_0002 VISTA 8:88457981-89059109
CIL_00085B CIL_00085B_0002 VISTA 8:88474689-89076074
CIL_00090J CIL_00090J_0002 VISTA 8:88479183-89079972
CIL_00090K CIL_00090K_0002 VISTA 8:88577161-89178261
CIL_00090L CIL_00090L_0002 VISTA 8:88581293-89181923
CIL_00090M CIL_00090M_0002 VISTA 8:88602694-89203557
CIL_00090N CIL_00090N_0002 VISTA 8:88624827-89225618
CIL_0003PS CIL_0003PS_0002 CGP 8:88626828-88688474
CIL_0008AU CIL_0008AU_0002 VISTA 8:88639020-89240224
CIL_0003PR CIL_0003PR_0002 CGP 8:88647315-88751945

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000737 IEA DNA catabolic process, endonucleolytic
GO:0002227 IMP innate immune response in mucosa
GO:0002253 IMP activation of immune response
GO:0002367 ISS cytokine production involved in immune response
GO:0002381 IMP immunoglobulin production involved in immunoglobulin mediated immune response
GO:0002606 IMP positive regulation of dendritic cell antigen processing and presentation
GO:0002710 IMP negative regulation of T cell mediated immunity
GO:0002732 IEA positive regulation of dendritic cell cytokine production
GO:0002830 ISS positive regulation of type 2 immune response
GO:0002862 IMP negative regulation of inflammatory response to antigenic stimulus
GO:0002925 IMP positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 ISS cytoplasm
GO:0005829 ISS cytosol
GO:0005856 ISS cytoskeleton
GO:0005886 ISS plasma membrane
GO:0006952 TAS defense response
GO:0006954 TAS inflammatory response
GO:0006963 IDA positive regulation of antibacterial peptide biosynthetic process
GO:0006965 IMP positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0007165 TAS signal transduction
GO:0007584 IEA response to nutrient
GO:0008180 ISS COP9 signalosome
GO:0008284 IEA positive regulation of cell proliferation
GO:0009595 TAS detection of biotic stimulus
GO:0009986 ISS cell surface
GO:0016045 ISS detection of bacterium
GO:0016888 IEA endodeoxyribonuclease activity, producing 5'-phosphomonoesters
GO:0019899 ISS enzyme binding
GO:0019901 ISS protein kinase binding
GO:0030277 IEA maintenance of gastrointestinal epithelium
GO:0031398 IDA positive regulation of protein ubiquitination
GO:0031982 ISS vesicle
GO:0032088 IMP negative regulation of NF-kappaB transcription factor activity
GO:0032494 IDA response to peptidoglycan
GO:0032495 ISS response to muramyl dipeptide
GO:0032496 IMP response to lipopolysaccharide
GO:0032498 ISS detection of muramyl dipeptide
GO:0032500 ISS muramyl dipeptide binding
GO:0032689 IMP negative regulation of interferon-gamma production
GO:0032695 IDA negative regulation of interleukin-12 production
GO:0032701 IMP negative regulation of interleukin-18 production
GO:0032703 IMP negative regulation of interleukin-2 production
GO:0032720 IMP negative regulation of tumor necrosis factor production
GO:0032731 IEA positive regulation of interleukin-1 beta production
GO:0032733 IMP positive regulation of interleukin-10 production
GO:0032735 IMP positive regulation of interleukin-12 production
GO:0032740 ISS positive regulation of interleukin-17 production
GO:0032755 IMP positive regulation of interleukin-6 production
GO:0032760 IMP positive regulation of tumor necrosis factor production
GO:0032874 ISO positive regulation of stress-activated MAPK cascade
GO:0034136 IMP negative regulation of toll-like receptor 2 signaling pathway
GO:0035419 IDA activation of MAPK activity involved in innate immune response
GO:0035556 ISS intracellular signal transduction
GO:0042742 ISS defense response to bacterium
GO:0042834 ISS peptidoglycan binding
GO:0042981 IEA regulation of apoptotic process
GO:0043123 ISS positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 ISS protein complex
GO:0043330 IMP response to exogenous dsRNA
GO:0043410 IMP positive regulation of MAPK cascade
GO:0043552 IMP positive regulation of phosphatidylinositol 3-kinase activity
GO:0044130 IMP negative regulation of growth of symbiont in host
GO:0045087 ISS innate immune response
GO:0045089 IMP positive regulation of innate immune response
GO:0045747 IDA positive regulation of Notch signaling pathway
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046330 ISO positive regulation of JNK cascade
GO:0050679 IMP positive regulation of epithelial cell proliferation
GO:0050700 ISS CARD domain binding
GO:0050718 ISS positive regulation of interleukin-1 beta secretion
GO:0050727 IMP regulation of inflammatory response
GO:0050731 IMP positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766 IMP positive regulation of phagocytosis
GO:0050830 IMP defense response to Gram-positive bacterium
GO:0050871 IEA positive regulation of B cell activation
GO:0051092 ISS positive regulation of NF-kappaB transcription factor activity
GO:0051259 TAS protein oligomerization
GO:0051353 IDA positive regulation of oxidoreductase activity
GO:0051770 IMP positive regulation of nitric-oxide synthase biosynthetic process
GO:0060585 IDA positive regulation of prostaglandin-endoperoxide synthase activity
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0070431 ISS nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071224 IMP cellular response to peptidoglycan
GO:0071225 ISS cellular response to muramyl dipeptide
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071608 IMP macrophage inflammatory protein-1 alpha production
GO:0090022 IMP regulation of neutrophil chemotaxis
GO:2000110 IDA negative regulation of macrophage apoptotic process
GO:2000363 IDA positive regulation of prostaglandin-E synthase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010756 nod2 nucleotide-binding oligomerization domain containing 2 protein_coding Danio_rerio
ENSG00000167207 NOD2 nucleotide-binding oligomerization domain containing 2 protein_coding Homo_sapiens

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