C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nucleotide-binding oligomerization domain containing 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000167207 NOD2 9606 + 16:50693603-50733077 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000300589 NOD2-001 50697139-50733077 protein_coding
  ENST00000524712 NOD2-008 50712194-50723374 nonsense_mediated_decay
  ENST00000526417 NOD2-003 50693603-50710951 processed_transcript
  ENST00000527052 NOD2-009 50712194-50723374 nonsense_mediated_decay
  ENST00000527070 NOD2-002 50697140-50710791 nonsense_mediated_decay
  ENST00000529633 NOD2-007 50712194-50723374 nonsense_mediated_decay
  ENST00000531674 NOD2-004 50693626-50699933 protein_coding
  ENST00000532206 NOD2-005 50697140-50710791 processed_transcript
  ENST00000534057 NOD2-010 50712194-50723374 protein_coding
  ENST00000534067 NOD2-006 50712194-50723374 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainColonHeartKidneyLiverLungMuscleOvaryPlacentaENST00000300589ENST00000524712ENST00000527070ENST00000529633ENST00000531674ENST00000534067
Transcript ID Adrenal Bladder Brain Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENST00000300589 0.181±0.00 0.106±0.00 0.011±0.00 N/A 0.018±0.00 0.015±0.00 0.080±0.00 0.187±0.00 N/A 0.311±0.05 N/A
ENST00000524712 N/A N/A N/A N/A N/A N/A 1.081±0.00 N/A N/A N/A N/A
ENST00000527070 N/A N/A N/A N/A N/A N/A N/A N/A 0.047±0.00 0.221±0.00 N/A
ENST00000529633 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.473±0.00
ENST00000531674 N/A N/A N/A 0.111±0.00 0.059±0.00 N/A N/A N/A N/A N/A N/A
ENST00000534067 N/A N/A N/A N/A N/A N/A N/A 0.913±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007ON CIL_0007ON_0001 UCNEbase 16:50459337-51906374
CIL_00090I CIL_00090I_0001 VISTA 16:50514444-51115745
CIL_00085B CIL_00085B_0001 VISTA 16:50535781-51137187
CIL_00090J CIL_00090J_0001 VISTA 16:50540952-51141798
CIL_00090K CIL_00090K_0001 VISTA 16:50643117-51244272
CIL_00090L CIL_00090L_0001 VISTA 16:50648118-51248778
CIL_0003PS CIL_0003PS_0001 CGP 16:50666300-50733077
CIL_00090M CIL_00090M_0001 VISTA 16:50676779-51277697
CIL_0003PR CIL_0003PR_0001 CGP 16:50693603-50801935

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 TAS activation of MAPK activity
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002227 IEA innate immune response in mucosa
GO:0002253 IEA activation of immune response
GO:0002367 IMP cytokine production involved in immune response
GO:0002381 IEA immunoglobulin production involved in immunoglobulin mediated immune response
GO:0002606 ISS positive regulation of dendritic cell antigen processing and presentation
GO:0002710 IEA negative regulation of T cell mediated immunity
GO:0002732 IEA positive regulation of dendritic cell cytokine production
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0002830 IMP positive regulation of type 2 immune response
GO:0002862 IEA negative regulation of inflammatory response to antigenic stimulus
GO:0002925 IEA positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 TAS cytoplasm
GO:0005829 IDA cytosol
GO:0005856 IDA cytoskeleton
GO:0005886 IDA plasma membrane
GO:0006952 TAS defense response
GO:0006963 IEA positive regulation of antibacterial peptide biosynthetic process
GO:0006965 IEA positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0007254 TAS JNK cascade
GO:0007584 IEA response to nutrient
GO:0008180 IDA COP9 signalosome
GO:0008284 IEA positive regulation of cell proliferation
GO:0009595 TAS detection of biotic stimulus
GO:0009986 IDA cell surface
GO:0016045 IDA detection of bacterium
GO:0019899 IPI enzyme binding
GO:0019901 IPI protein kinase binding
GO:0030277 IMP maintenance of gastrointestinal epithelium
GO:0031982 IDA vesicle
GO:0032088 IEA negative regulation of NF-kappaB transcription factor activity
GO:0032494 IEA response to peptidoglycan
GO:0032495 IDA response to muramyl dipeptide
GO:0032496 IEA response to lipopolysaccharide
GO:0032498 IDA detection of muramyl dipeptide
GO:0032500 IDA muramyl dipeptide binding
GO:0032689 IEA negative regulation of interferon-gamma production
GO:0032695 IEA negative regulation of interleukin-12 production
GO:0032701 IEA negative regulation of interleukin-18 production
GO:0032703 IEA negative regulation of interleukin-2 production
GO:0032720 IEA negative regulation of tumor necrosis factor production
GO:0032731 IMP positive regulation of interleukin-1 beta production
GO:0032733 ISS positive regulation of interleukin-10 production
GO:0032735 IEA positive regulation of interleukin-12 production
GO:0032740 IMP positive regulation of interleukin-17 production
GO:0032755 IDA positive regulation of interleukin-6 production
GO:0032760 IDA positive regulation of tumor necrosis factor production
GO:0032874 IDA positive regulation of stress-activated MAPK cascade
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034136 IEA negative regulation of toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035419 ISS activation of MAPK activity involved in innate immune response
GO:0035556 IDA intracellular signal transduction
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042742 IDA defense response to bacterium
GO:0042834 IDA peptidoglycan binding
GO:0042981 IEA regulation of apoptotic process
GO:0043123 IDA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 IDA protein complex
GO:0043330 IEA response to exogenous dsRNA
GO:0043410 IEA positive regulation of MAPK cascade
GO:0043552 ISS positive regulation of phosphatidylinositol 3-kinase activity
GO:0044130 IEA negative regulation of growth of symbiont in host
GO:0045087 NAS innate immune response
GO:0045089 IEA positive regulation of innate immune response
GO:0045747 ISS positive regulation of Notch signaling pathway
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IDA positive regulation of JNK cascade
GO:0046645 ISS positive regulation of gamma-delta T cell activation
GO:0050679 ISS positive regulation of epithelial cell proliferation
GO:0050700 IPI CARD domain binding
GO:0050718 IDA positive regulation of interleukin-1 beta secretion
GO:0050727 IC regulation of inflammatory response
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766 IEA positive regulation of phagocytosis
GO:0050830 IEA defense response to Gram-positive bacterium
GO:0050871 IDA positive regulation of B cell activation
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051259 TAS protein oligomerization
GO:0051353 ISS positive regulation of oxidoreductase activity
GO:0051403 TAS stress-activated MAPK cascade
GO:0051770 ISS positive regulation of nitric-oxide synthase biosynthetic process
GO:0060585 ISS positive regulation of prostaglandin-endoperoxide synthase activity
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0070431 IDA nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071224 IEA cellular response to peptidoglycan
GO:0071225 IDA cellular response to muramyl dipeptide
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071608 IEA macrophage inflammatory protein-1 alpha production
GO:0090022 IEA regulation of neutrophil chemotaxis
GO:2000110 ISS negative regulation of macrophage apoptotic process
GO:2000363 ISS positive regulation of prostaglandin-E synthase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010756 nod2 nucleotide-binding oligomerization domain containing 2 protein_coding Danio_rerio
ENSMUSG00000055994 Nod2 nucleotide-binding oligomerization domain containing 2 protein_coding Mus_musculus

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