C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rho guanine nucleotide exchange factor (GEF) 12
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000059495 Arhgef12 10090 - 9:42963842-43105718 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000072767 Arhgef12-201 42963843-43105486 protein_coding
  ENSMUST00000165665 Arhgef12-202 42963842-43105718 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000072767ENSMUST00000165665
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000072767 N/A N/A 5.051±3.23 5.499±3.78 8.753±0.00 1.342±0.09 2.131±0.00 N/A 1.359±0.58 N/A 2.558±0.95 8.720±2.79 4.923±2.47 0.874±0.54
ENSMUST00000165665 8.120±1.64 7.042±1.36 6.405±2.36 5.017±1.78 4.436±0.66 2.356±0.35 12.879±1.07 16.571±2.26 4.843±2.41 18.814±5.32 3.220±1.56 6.898±1.82 5.729±2.73 2.882±0.52

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003MJ CIL_0003MJ_0002 CGP 9:42963842-43116570

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001664 IEA G-protein coupled receptor binding
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005096 IEA GTPase activator activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0016020 IEA membrane
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035556 IEA intracellular signal transduction
GO:0038032 IEA termination of G-protein coupled receptor signaling pathway
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030532 ARHGEF12 (1 of 2) Rho guanine nucleotide exchange factor (GEF) 12 protein_coding Danio_rerio
ENSDARG00000067634 arhgef12b Rho guanine nucleotide exchange factor (GEF) 12b protein_coding Danio_rerio
ENSG00000196914 ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 protein_coding Homo_sapiens

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