C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rho guanine nucleotide exchange factor (GEF) 12
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196914 ARHGEF12 9606 + 11:120336914-120489936 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000356641 ARHGEF12-015 120336914-120487060 protein_coding
  ENST00000397843 ARHGEF12-001 120337078-120489936 protein_coding
  ENST00000525222 ARHGEF12-012 120449275-120459194 retained_intron
  ENST00000525960 ARHGEF12-009 120445422-120447266 retained_intron
  ENST00000526067 ARHGEF12-014 120475975-120480107 retained_intron
  ENST00000528225 ARHGEF12-008 120438448-120451633 retained_intron
  ENST00000528681 ARHGEF12-007 120477000-120477573 retained_intron
  ENST00000529970 ARHGEF12-006 120385321-120477646 retained_intron
  ENST00000530388 ARHGEF12-005 120405933-120411837 retained_intron
  ENST00000530747 ARHGEF12-013 120457718-120467308 retained_intron
  ENST00000531616 ARHGEF12-010 120462549-120473127 retained_intron
  ENST00000532823 ARHGEF12-011 120448494-120457752 retained_intron
  ENST00000532993 ARHGEF12-003 120385294-120489034 protein_coding
  ENST00000612968 ARHGEF12-016 120457051-120459339 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000356641ENST00000397843ENST00000529970ENST00000532993
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000356641 N/A N/A N/A 6.880±0.00 8.531±0.00 N/A N/A N/A N/A 1.891±0.00 2.738±0.00 N/A 2.201±0.00
ENST00000397843 2.911±0.00 11.924±0.00 6.803±1.80 4.594±2.69 4.013±0.00 1.984±0.00 4.634±1.21 6.452±0.00 3.974±0.70 1.430±0.61 2.962±1.11 1.571±0.14 N/A
ENST00000529970 N/A N/A 13.879±0.00 6.649±0.00 N/A N/A N/A N/A N/A 2.076±0.00 N/A N/A N/A
ENST00000532993 10.825±0.00 N/A 10.155±3.11 7.388±0.00 7.599±2.95 4.824±0.28 10.948±4.42 3.484±0.00 8.450±2.46 N/A 7.446±3.22 6.115±0.00 6.024±2.35

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00021Z CIL_00021Z_0002 CGP 11:120325129-120489936

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001664 IDA G-protein coupled receptor binding
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005096 IEA GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005737 IEA:IDA cytoplasm
GO:0005829 TAS cytosol
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007411 TAS axon guidance
GO:0016020 IEA membrane
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0038032 IEA termination of G-protein coupled receptor signaling pathway
GO:0043065 TAS positive regulation of apoptotic process
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0070062 IDA extracellular vesicular exosome
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030532 ARHGEF12 (1 of 2) Rho guanine nucleotide exchange factor (GEF) 12 protein_coding Danio_rerio
ENSDARG00000067634 arhgef12b Rho guanine nucleotide exchange factor (GEF) 12b protein_coding Danio_rerio
ENSMUSG00000059495 Arhgef12 Rho guanine nucleotide exchange factor (GEF) 12 protein_coding Mus_musculus

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