C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mohawk homeobox
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000061013 Mkx 10090 - 18:6910459-7004780 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000079788 Mkx-001 6934966-7004780 protein_coding
  ENSMUST00000176586 Mkx-004 6910459-6936621 processed_transcript
  ENSMUST00000176608 Mkx-003 7000636-7003782 processed_transcript
  ENSMUST00000176757 Mkx-002 7002304-7004726 retained_intron
  ENSMUST00000188926 Mkx-005 6936952-6992988 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000079788ENSMUST00000176608ENSMUST00000176757ENSMUST00000188926
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000079788 0.192±0.18 1.477±0.11 0.197±0.06 0.459±0.35 0.040±0.01 1.838±0.79 0.029±0.00 0.106±0.05 0.157±0.12 0.092±0.06 0.118±0.04 3.594±1.39 0.225±0.07 0.114±0.06
ENSMUST00000176608 N/A N/A 0.482±0.00 0.969±0.00 0.099±0.06 N/A 0.057±0.00 0.080±0.00 0.092±0.03 0.118±0.07 0.327±0.00 N/A N/A 0.219±0.09
ENSMUST00000176757 N/A 4.609±1.78 N/A N/A 0.163±0.06 3.114±0.97 0.146±0.08 0.107±0.00 0.667±0.20 0.216±0.07 0.360±0.00 10.034±3.37 0.559±0.00 0.295±0.00
ENSMUST00000188926 0.347±0.00 N/A N/A 4.455±0.00 0.139±0.06 N/A 0.177±0.01 0.431±0.00 0.170±0.00 N/A 0.171±0.00 12.900±0.00 0.589±0.11 0.184±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00077Z CIL_00077Z_0003 CGP 18:6765205-7004780
CIL_00077Y CIL_00077Y_0003 CGP 18:6910459-7297901

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085 IPI RNA polymerase II transcription factor binding
GO:0002932 IMP tendon sheath development
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005667 IC transcription factor complex
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007517 IEP muscle organ development
GO:0010468 IMP regulation of gene expression
GO:0010628 IMP positive regulation of gene expression
GO:0030199 IMP collagen fibril organization
GO:0032967 IMP positive regulation of collagen biosynthetic process
GO:0035990 IMP tendon cell differentiation
GO:0035992 IMP tendon formation
GO:0043565 IEA sequence-specific DNA binding
GO:0045662 IDA negative regulation of myoblast differentiation
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075026 mkxb mohawk homeobox b protein_coding Danio_rerio
ENSDARG00000075450 mkxa mohawk homeobox a protein_coding Danio_rerio
ENSG00000150051 MKX mohawk homeobox protein_coding Homo_sapiens

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