C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sphingosine kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000061878 Sphk1 10090 + 11:116530925-116536674 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000063396 Sphk1-006 116532925-116536657 protein_coding
  ENSMUST00000063446 Sphk1-005 116532473-116536674 protein_coding
  ENSMUST00000100201 Sphk1-001 116531911-116536670 protein_coding
  ENSMUST00000106386 Sphk1-004 116532444-116536674 protein_coding
  ENSMUST00000106387 Sphk1-002 116531744-116536657 protein_coding
  ENSMUST00000106388 Sphk1-003 116530925-116536657 protein_coding
  ENSMUST00000124682 Sphk1-014 116533575-116535698 protein_coding
  ENSMUST00000134834 Sphk1-016 116532451-116536668 retained_intron
  ENSMUST00000136526 Sphk1-009 116531162-116535284 retained_intron
  ENSMUST00000138840 Sphk1-008 116531121-116535700 protein_coding
  ENSMUST00000141798 Sphk1-007 116534740-116536670 protein_coding
  ENSMUST00000145737 Sphk1-010 116532454-116535712 protein_coding
  ENSMUST00000148185 Sphk1-015 116534160-116535288 retained_intron
  ENSMUST00000150658 Sphk1-013 116533251-116535636 processed_transcript
  ENSMUST00000154034 Sphk1-012 116533268-116535995 protein_coding
  ENSMUST00000155102 Sphk1-011 116532457-116535341 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000063396ENSMUST00000063446ENSMUST00000100201ENSMUST00000106386ENSMUST00000106387ENSMUST00000106388ENSMUST00000124682ENSMUST00000134834ENSMUST00000138840ENSMUST00000141798ENSMUST00000145737ENSMUST00000148185ENSMUST00000150658ENSMUST00000154034ENSMUST00000155102
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000063396 N/A 0.178±0.02 N/A 0.183±0.00 N/A 0.455±0.02 N/A 0.508±0.00 0.012±0.00 N/A 0.136±0.05 1.525±0.27 0.665±0.00 N/A
ENSMUST00000063446 1.598±0.37 0.241±0.00 1.669±0.24 0.191±0.00 0.670±0.23 0.560±0.09 N/A 1.010±0.43 1.636±1.03 4.177±1.48 0.052±0.00 1.703±0.39 0.444±0.00 0.307±0.11
ENSMUST00000100201 N/A N/A N/A N/A N/A N/A N/A N/A 0.082±0.00 N/A 0.309±0.00 N/A 0.931±0.00 N/A
ENSMUST00000106386 N/A N/A N/A 0.213±0.00 N/A 0.816±0.00 N/A 0.779±0.06 3.911±1.96 2.338±0.00 0.363±0.13 3.003±0.00 0.578±0.27 0.490±0.00
ENSMUST00000106387 N/A N/A N/A N/A 0.621±0.00 N/A N/A N/A N/A N/A 0.276±0.00 0.586±0.00 0.456±0.00 N/A
ENSMUST00000106388 N/A N/A N/A N/A N/A N/A 0.326±0.00 N/A N/A N/A N/A 1.017±0.36 1.548±0.00 N/A
ENSMUST00000124682 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.173±0.00 N/A N/A N/A
ENSMUST00000134834 1.067±0.54 0.134±0.05 1.644±0.66 0.149±0.03 0.267±0.10 0.385±0.09 0.163±0.00 0.425±0.09 1.091±0.96 2.165±0.58 0.042±0.01 1.103±0.34 0.313±0.12 0.225±0.08
ENSMUST00000138840 N/A N/A N/A N/A N/A N/A 0.335±0.00 N/A 0.104±0.02 N/A N/A N/A N/A N/A
ENSMUST00000141798 3.121±1.04 0.762±0.19 4.320±0.32 0.437±0.08 1.519±0.66 1.919±0.60 0.689±0.15 2.478±0.61 5.772±5.27 8.631±1.26 0.093±0.00 5.746±2.47 1.024±0.74 0.549±0.30
ENSMUST00000145737 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.216±0.00 N/A N/A N/A
ENSMUST00000148185 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.187±0.04 N/A N/A N/A
ENSMUST00000150658 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.185±0.00 3.721±0.00 N/A N/A
ENSMUST00000154034 N/A N/A N/A N/A N/A 1.584±0.00 N/A N/A 0.091±0.00 N/A 0.189±0.08 3.355±0.56 N/A N/A
ENSMUST00000155102 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.272±0.14 1.360±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008WF CIL_0008WF_0002 VISTA 11:116019003-116619995
CIL_00009I CIL_00009I_0002 CGP 11:116470845-116536674
CIL_00079O CIL_00079O_0002 CGP 11:116530925-116581447

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 ISS magnesium ion binding
GO:0001568 IGI blood vessel development
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0001956 IEA positive regulation of neurotransmitter secretion
GO:0003677 ISA DNA binding
GO:0003951 IEA NAD+ kinase activity
GO:0004143 IEA diacylglycerol kinase activity
GO:0005515 IEA protein binding
GO:0005516 ISA calmodulin binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 ISS cytoplasm
GO:0005829 IEA cytosol
GO:0005886 ISS plasma membrane
GO:0006670 ISS sphingosine metabolic process
GO:0006954 IMP inflammatory response
GO:0007205 IEA protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007420 IGI brain development
GO:0007565 IEA female pregnancy
GO:0008021 IEA synaptic vesicle
GO:0008284 IGI positive regulation of cell proliferation
GO:0008481 ISA sphinganine kinase activity
GO:0009267 IEA cellular response to starvation
GO:0010803 ISS regulation of tumor necrosis factor-mediated signaling pathway
GO:0010976 IEA positive regulation of neuron projection development
GO:0014070 IEA response to organic cyclic compound
GO:0014075 IEA response to amine
GO:0017050 ISS D-erythro-sphingosine kinase activity
GO:0019371 IEA cyclooxygenase pathway
GO:0019722 IEA calcium-mediated signaling
GO:0030307 IEA positive regulation of cell growth
GO:0030335 IEA positive regulation of cell migration
GO:0030424 IEA axon
GO:0031398 ISS positive regulation of protein ubiquitination
GO:0032026 IEA response to magnesium ion
GO:0032570 IEA response to progesterone
GO:0032651 IMP regulation of interleukin-1 beta production
GO:0033198 IEA response to ATP
GO:0042346 ISS positive regulation of NF-kappaB import into nucleus
GO:0043005 IEA neuron projection
GO:0043066 IEA negative regulation of apoptotic process
GO:0045766 IEA positive regulation of angiogenesis
GO:0045931 IEA positive regulation of mitotic cell cycle
GO:0045987 IEA positive regulation of smooth muscle contraction
GO:0046834 ISA:IEA lipid phosphorylation
GO:0048146 IEA positive regulation of fibroblast proliferation
GO:0051092 ISS positive regulation of NF-kappaB transcription factor activity
GO:0051721 IEA protein phosphatase 2A binding
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0070555 IEA response to interleukin-1
GO:0071363 IEA cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079139 SPHK1 sphingosine kinase 1 protein_coding Danio_rerio
ENSG00000176170 SPHK1 sphingosine kinase 1 protein_coding Homo_sapiens

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