C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NLR family, CARD domain containing 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000074151 Nlrc5 10090 + 8:94472763-94527272 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000053085 Nlrc5-003 94472763-94527272 protein_coding
  ENSMUST00000098489 Nlrc5-201 94525067-94527264 protein_coding
  ENSMUST00000137032 Nlrc5-001 94525067-94527268 retained_intron
  ENSMUST00000182409 Nlrc5-004 94476126-94506778 retained_intron
  ENSMUST00000183132 Nlrc5-005 94482039-94491589 nonsense_mediated_decay
  ENSMUST00000183287 Nlrc5-006 94521431-94523509 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000053085ENSMUST00000098489ENSMUST00000137032ENSMUST00000182409
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000053085 4.579±1.90 1.249±0.62 2.110±0.49 0.042±0.02 8.274±1.66 0.367±0.20 0.524±0.15 0.769±0.27 1.001±0.93 2.014±0.86 0.224±0.01 0.919±0.48 N/A N/A
ENSMUST00000098489 N/A N/A 2.469±0.00 0.072±0.02 6.795±1.81 N/A N/A N/A 1.673±1.51 2.494±0.00 0.364±0.15 1.449±0.00 1.260±0.31 0.885±0.06
ENSMUST00000137032 N/A 2.643±0.32 4.541±0.00 0.036±0.00 N/A N/A N/A N/A 0.238±0.20 N/A 0.193±0.00 N/A 0.293±0.00 N/A
ENSMUST00000182409 N/A 0.907±0.00 N/A N/A N/A N/A N/A 0.331±0.00 0.762±0.00 1.107±0.00 0.364±0.00 0.711±0.23 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00051Y CIL_00051Y_0003 CGP 8:94472763-94570529

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0005829 IDA cytosol
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0043549 IEA regulation of kinase activity
GO:0045087 IMP innate immune response
GO:0045345 IEA positive regulation of MHC class I biosynthetic process
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0051607 ISS defense response to virus
GO:0060335 ISS positive regulation of interferon-gamma-mediated signaling pathway
GO:0060339 IDA negative regulation of type I interferon-mediated signaling pathway
GO:0060340 ISS positive regulation of type I interferon-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000024631 NLRC5 NLR family, CARD domain containing 5 protein_coding Danio_rerio
ENSG00000140853 NLRC5 NLR family, CARD domain containing 5 protein_coding Homo_sapiens

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