C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutathione peroxidase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000075706 Gpx4 10090 + 10:80047166-80056439 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000097227 Gpx4-002 80054037-80056439 protein_coding
  ENSMUST00000105372 Gpx4-001 80053488-80056439 protein_coding
  ENSMUST00000136081 Gpx4-005 80055998-80056363 retained_intron
  ENSMUST00000144698 Gpx4-006 80047166-80056439 processed_transcript
  ENSMUST00000145703 Gpx4-003 80054035-80055107 processed_transcript
  ENSMUST00000154095 Gpx4-004 80055894-80056365 retained_intron
  ENSMUST00000183037 Gpx4-007 80054465-80056394 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000097227ENSMUST00000105372ENSMUST00000136081ENSMUST00000145703ENSMUST00000183037
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000097227 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 30.104±0.00 N/A 344.108±197.75
ENSMUST00000105372 157.006±80.37 223.375±47.75 67.947±18.77 47.987±12.27 171.886±26.84 69.435±8.25 110.640±30.63 204.579±14.66 84.244±31.38 95.034±17.44 161.847±19.23 74.367±23.27 136.482±10.81 768.107±518.27
ENSMUST00000136081 N/A 921.616±174.38 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 554.738±46.62 N/A
ENSMUST00000145703 461.329±289.82 N/A N/A 79.634±0.00 361.743±215.73 N/A 211.910±52.56 272.342±88.23 155.969±0.00 89.868±11.64 N/A 161.288±71.03 N/A N/A
ENSMUST00000183037 716.845±227.28 416.072±80.72 294.206±21.67 66.938±1.38 507.355±207.86 197.339±22.52 343.060±36.54 835.230±40.85 275.084±76.33 371.329±17.99 98.009±18.97 301.084±55.70 197.350±54.32 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008XG CIL_0008XG_0002 VISTA 10:79539861-80142369
CIL_0000QU CIL_0000QU_0002 CGP 10:80035949-80056439
CIL_0000QT CIL_0000QT_0002 CGP 10:80047166-80102698

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004602 IDA glutathione peroxidase activity
GO:0005634 IEA nucleus
GO:0005635 IDA nuclear envelope
GO:0005739 IDA mitochondrion
GO:0005743 IDA mitochondrial inner membrane
GO:0005829 IDA cytosol
GO:0006325 IDA chromatin organization
GO:0006749 IEA glutathione metabolic process
GO:0006979 IEA response to oxidative stress
GO:0007275 IEA multicellular organismal development
GO:0007283 IDA spermatogenesis
GO:0007568 IEA aging
GO:0008430 IEA selenium binding
GO:0032355 IEA response to estradiol
GO:0042744 IEA hydrogen peroxide catabolic process
GO:0043295 IEA glutathione binding
GO:0047066 IEA phospholipid-hydroperoxide glutathione peroxidase activity
GO:0050727 IEA regulation of inflammatory response
GO:0055114 IEA oxidation-reduction process
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068478 gpx4a glutathione peroxidase 4a protein_coding Danio_rerio
ENSDARG00000076836 gpx4b glutathione peroxidase 4b protein_coding Danio_rerio
ENSG00000167468 GPX4 glutathione peroxidase 4 protein_coding Homo_sapiens

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