C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutathione peroxidase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000167468 GPX4 9606 + 19:1103926-1106791 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000354171 GPX4-002 1103937-1106790 protein_coding
  ENST00000585362 GPX4-004 1104415-1105761 protein_coding
  ENST00000585480 GPX4-008 1105454-1106779 non_stop_decay
  ENST00000587648 GPX4-009 1105152-1106564 protein_coding
  ENST00000587932 GPX4-005 1105253-1105673 retained_intron
  ENST00000588919 GPX4-003 1104073-1106788 protein_coding
  ENST00000589115 GPX4-007 1104008-1106779 protein_coding
  ENST00000592940 GPX4-001 1105156-1106791 retained_intron
  ENST00000593032 GPX4-006 1104067-1106443 protein_coding
  ENST00000611653 GPX4-011 1104052-1106779 protein_coding
  ENST00000614791 GPX4-010 1104706-1105483 protein_coding
  ENST00000616066 GPX4-201 1103926-1106787 protein_coding
  ENST00000622390 GPX4-202 1104650-1106787 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000354171ENST00000587648ENST00000589115ENST00000593032ENST00000611653ENST00000622390
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000354171 N/A N/A N/A N/A N/A N/A 3.662±0.00 N/A N/A N/A N/A N/A N/A 145.321±110.10
ENST00000587648 N/A N/A 9.247±0.00 N/A 8.959±0.00 5.933±0.00 N/A N/A 9.770±0.00 10.955±0.00 35.264±0.00 12.681±0.00 16.592±0.00 67.682±0.00
ENST00000589115 N/A 29.052±0.00 N/A 120.015±0.00 305.096±0.00 2.982±0.00 N/A N/A N/A N/A N/A N/A N/A 177.135±0.00
ENST00000593032 N/A N/A N/A N/A N/A 4.978±0.00 4.929±0.00 N/A N/A 5.978±0.00 N/A 5.023±0.00 N/A N/A
ENST00000611653 725.606±0.00 167.515±0.00 16.450±0.00 153.684±39.73 487.422±464.36 147.065±132.12 87.015±72.33 195.961±74.04 117.265±88.77 210.163±197.88 267.516±199.35 164.241±152.28 220.672±118.71 295.833±105.23
ENST00000622390 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 104.229±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000QU CIL_0000QU_0001 CGP 19:1086579-1106791
CIL_0000QT CIL_0000QT_0001 CGP 19:1103926-1174283

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004602 TAS:IEA glutathione peroxidase activity
GO:0005634 IDA nucleus
GO:0005739 TAS mitochondrion
GO:0005829 TAS cytosol
GO:0006644 TAS phospholipid metabolic process
GO:0006749 IEA glutathione metabolic process
GO:0006979 IEA response to oxidative stress
GO:0007275 IEA multicellular organismal development
GO:0007568 IEA aging
GO:0008430 IEA selenium binding
GO:0019369 TAS arachidonic acid metabolic process
GO:0019372 TAS lipoxygenase pathway
GO:0032355 IEA response to estradiol
GO:0042744 IEA hydrogen peroxide catabolic process
GO:0043295 IEA glutathione binding
GO:0044281 TAS small molecule metabolic process
GO:0047066 IEA phospholipid-hydroperoxide glutathione peroxidase activity
GO:0050727 IEA regulation of inflammatory response
GO:0055114 TAS:IEA oxidation-reduction process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068478 gpx4a glutathione peroxidase 4a protein_coding Danio_rerio
ENSDARG00000076836 gpx4b glutathione peroxidase 4b protein_coding Danio_rerio
ENSMUSG00000075706 Gpx4 glutathione peroxidase 4 protein_coding Mus_musculus

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