C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: calpain 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000079110 Capn3 10090 + 2:120456019-120504913 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000028748 Capn3-004 120476920-120504913 protein_coding
  ENSMUST00000028749 Capn3-001 120463579-120504913 protein_coding
  ENSMUST00000090028 Capn3-005 120476970-120504913 protein_coding
  ENSMUST00000110716 Capn3-003 120476918-120504913 protein_coding
  ENSMUST00000110719 Capn3-006 120476976-120504913 protein_coding
  ENSMUST00000110721 Capn3-002 120463579-120504913 protein_coding
  ENSMUST00000124129 Capn3-009 120456019-120504773 processed_transcript
  ENSMUST00000125238 Capn3-012 120500242-120503216 processed_transcript
  ENSMUST00000139336 Capn3-008 120476976-120504514 processed_transcript
  ENSMUST00000141181 Capn3-013 120501229-120503041 processed_transcript
  ENSMUST00000145993 Capn3-007 120456019-120504913 processed_transcript
  ENSMUST00000151342 Capn3-010 120501303-120503394 processed_transcript
  ENSMUST00000151924 Capn3-011 120484351-120484625 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastLiverMuscleENSMUST00000028749ENSMUST00000110721ENSMUST00000145993
Transcript ID Breast Liver Muscle
ENSMUST00000028749 9.309±0.68 N/A 55.969±3.57
ENSMUST00000110721 N/A 3.649±0.00 N/A
ENSMUST00000145993 13.790±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005PL CIL_0005PL_0002 CGP 2:120355312-120461700
CIL_0004QL CIL_0004QL_0003 CGP 2:120403896-120504913
CIL_0004QM CIL_0004QM_0003 CGP 2:120456019-120563843

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001896 IDA autolysis
GO:0003824 ISS catalytic activity
GO:0004198 IDA calcium-dependent cysteine-type endopeptidase activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0006461 IMP protein complex assembly
GO:0006508 IDA proteolysis
GO:0008233 ISS peptidase activity
GO:0008307 IMP structural constituent of muscle
GO:0014718 IDA positive regulation of satellite cell activation involved in skeletal muscle regeneration
GO:0014850 ISS response to muscle activity
GO:0030016 ISS myofibril
GO:0030018 ISS Z disc
GO:0030239 IMP myofibril assembly
GO:0030315 ISS T-tubule
GO:0031402 IDA sodium ion binding
GO:0031432 ISS titin binding
GO:0032947 IMP protein complex scaffold
GO:0033234 ISS negative regulation of protein sumoylation
GO:0043066 IMP negative regulation of apoptotic process
GO:0043122 IMP regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 IDA protein complex
GO:0045214 IMP sarcomere organization
GO:0045661 IDA regulation of myoblast differentiation
GO:0045862 IDA positive regulation of proteolysis
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0050790 ISS regulation of catalytic activity
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0051281 IMP positive regulation of release of sequestered calcium ion into cytosol
GO:0051592 ISS response to calcium ion
GO:0055103 ISS ligase regulator activity
GO:0061061 IMP muscle structure development
GO:0070315 IDA G1 to G0 transition involved in cell differentiation
GO:0071277 IDA cellular response to calcium ion
GO:0071472 IDA cellular response to salt stress
GO:0072657 IMP protein localization to membrane
GO:0097264 ISS self proteolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041864 capn3a calpain 3a, (p94) protein_coding Danio_rerio
ENSDARG00000043035 capn3b calpain 3b protein_coding Danio_rerio
ENSG00000092529 CAPN3 calpain 3, (p94) protein_coding Homo_sapiens

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