C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mediator complex subunit 12
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000079487 Med12 10090 + X:101274030-101297465 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000087948 Med12-001 101274260-101297465 protein_coding
  ENSMUST00000087956 Med12-003 101274260-101297465 protein_coding
  ENSMUST00000117203 Med12-005 101274229-101297465 protein_coding
  ENSMUST00000117706 Med12-004 101274030-101297465 protein_coding
  ENSMUST00000132269 Med12-008 101293134-101296067 processed_transcript
  ENSMUST00000137664 Med12-009 101296569-101297387 processed_transcript
  ENSMUST00000146877 Med12-007 101283186-101283928 processed_transcript
  ENSMUST00000148846 Med12-002 101286024-101297465 retained_intron
  ENSMUST00000156131 Med12-006 101282696-101284157 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000087948ENSMUST00000087956ENSMUST00000117203ENSMUST00000117706ENSMUST00000132269ENSMUST00000137664ENSMUST00000148846
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000087948 6.534±2.36 5.457±0.23 5.832±0.51 9.316±3.06 7.054±1.89 4.747±0.81 3.200±0.63 3.171±0.63 3.703±2.75 9.421±1.60 2.735±0.71 10.434±3.63 8.307±3.30 3.799±0.50
ENSMUST00000087956 3.535±1.11 6.197±1.51 N/A N/A 3.772±0.83 7.174±2.02 1.405±0.13 2.107±1.03 1.472±0.48 3.477±1.07 1.138±0.29 8.825±3.42 2.613±0.42 1.032±0.55
ENSMUST00000117203 N/A N/A N/A N/A 11.230±0.00 N/A 1.626±0.00 N/A N/A N/A 1.497±0.74 3.154±0.00 3.103±0.59 N/A
ENSMUST00000117706 3.937±0.87 3.754±0.17 2.416±0.24 N/A 4.226±0.74 2.478±0.00 1.942±0.25 1.736±0.22 1.476±0.75 3.730±1.00 0.950±0.20 5.147±0.66 2.797±0.99 1.278±0.36
ENSMUST00000132269 11.288±0.00 32.098±5.72 N/A N/A 25.042±2.95 30.508±6.18 9.797±0.00 11.232±2.13 7.158±1.82 17.830±1.78 N/A 42.456±2.99 N/A N/A
ENSMUST00000137664 N/A 47.433±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000148846 5.355±1.66 8.707±1.33 4.435±0.42 N/A 8.611±3.51 11.661±2.53 2.643±0.52 3.588±0.92 3.509±1.59 6.302±0.07 2.145±0.00 22.401±4.00 2.496±0.02 2.450±0.23

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00057U CIL_00057U_0002 CGP X:101264378-101297465
CIL_00057X CIL_00057X_0002 CGP X:101274030-101325963

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000980 IDA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001104 IEA RNA polymerase II transcription cofactor activity
GO:0001190 IGI RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001843 IMP neural tube closure
GO:0003682 IDA chromatin binding
GO:0003712 IEA transcription cofactor activity
GO:0003713 IEA transcription coactivator activity
GO:0004872 IEA receptor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006367 IEA transcription initiation from RNA polymerase II promoter
GO:0007507 IMP heart development
GO:0008013 IEA beta-catenin binding
GO:0008022 IEA protein C-terminus binding
GO:0008134 IPI transcription factor binding
GO:0014003 IMP oligodendrocyte development
GO:0014044 IMP Schwann cell development
GO:0016020 IEA membrane
GO:0016592 IDA mediator complex
GO:0019827 IMP stem cell maintenance
GO:0019904 IEA protein domain specific binding
GO:0030178 IEA negative regulation of Wnt signaling pathway
GO:0030518 IEA intracellular steroid hormone receptor signaling pathway
GO:0030521 IEA androgen receptor signaling pathway
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046966 IEA thyroid hormone receptor binding
GO:0060070 IMP canonical Wnt signaling pathway
GO:0060071 IMP Wnt signaling pathway, planar cell polarity pathway
GO:0090245 IMP axis elongation involved in somitogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056800 med12 mediator of RNA polymerase II transcription, subunit 12 homolog protein_coding Danio_rerio
ENSG00000184634 MED12 mediator complex subunit 12 protein_coding Homo_sapiens

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