C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ring finger protein 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000090083 Rnf8 10090 + 17:29614790-29641664 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000024817 Rnf8-001 29614790-29641664 protein_coding
  ENSMUST00000161242 Rnf8-005 29631532-29641535 retained_intron
  ENSMUST00000161952 Rnf8-002 29614890-29619557 processed_transcript
  ENSMUST00000162417 Rnf8-004 29628636-29635929 retained_intron
  ENSMUST00000162588 Rnf8-003 29614822-29627040 protein_coding
  ENSMUST00000172485 Rnf8-007 29614854-29641587 nonsense_mediated_decay
  ENSMUST00000172800 Rnf8-008 29634486-29641556 retained_intron
  ENSMUST00000173449 Rnf8-009 29616136-29627073 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainColonKidneyLiverLungMuscleOvaryPlacentaENSMUST00000024817ENSMUST00000172485
Transcript ID Adipose Adrenal Brain Colon Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000024817 17.791±0.67 N/A 18.313±0.00 17.766±0.75 13.658±0.52 14.952±3.60 17.665±0.76 6.472±0.74 26.085±9.98 13.155±1.33
ENSMUST00000172485 N/A 37.743±5.11 N/A 20.691±2.04 N/A 12.626±0.00 N/A N/A 28.943±4.59 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00089L CIL_00089L_0002 VISTA 17:29133661-29735358
CIL_0005CZ CIL_0005CZ_0002 CGP 17:29549788-29641664

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000151 ISS ubiquitin ligase complex
GO:0000781 IDA chromosome, telomeric region
GO:0003682 ISS chromatin binding
GO:0004842 IMP ubiquitin-protein transferase activity
GO:0005634 ISS nucleus
GO:0006302 ISS double-strand break repair
GO:0006303 IMP double-strand break repair via nonhomologous end joining
GO:0006511 ISS ubiquitin-dependent protein catabolic process
GO:0006974 ISS cellular response to DNA damage stimulus
GO:0007067 IEA mitotic nuclear division
GO:0007286 IMP spermatid development
GO:0008270 ISS zinc ion binding
GO:0010212 ISS response to ionizing radiation
GO:0016881 IEA acid-amino acid ligase activity
GO:0033522 IMP histone H2A ubiquitination
GO:0033523 IMP histone H2B ubiquitination
GO:0034244 ISS negative regulation of transcription elongation from RNA polymerase II promoter
GO:0035861 ISS site of double-strand break
GO:0042393 IMP histone binding
GO:0042803 ISS protein homodimerization activity
GO:0043486 IMP histone exchange
GO:0045190 IMP isotype switching
GO:0045739 ISS positive regulation of DNA repair
GO:0070534 ISS protein K63-linked ubiquitination
GO:0070535 ISS histone H2A K63-linked ubiquitination
GO:0070936 ISS protein K48-linked ubiquitination

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044949 rnf8 ring finger protein 8, E3 ubiquitin protein ligase protein_coding Danio_rerio
ENSG00000112130 RNF8 ring finger protein 8, E3 ubiquitin protein ligase protein_coding Homo_sapiens

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