C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: topoisomerase (DNA) II beta 180kDa
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000264331 TOP2B-201 ENSG00000077097 9606 - 3:25597905-25664372 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastLiverOvaryPlacentaENST00000264331
Transcript ID Adrenal Bladder Brain Breast Liver Ovary Placenta
ENST00000264331 5.772±0.00 2.106±0.00 3.410±0.00 5.334±0.00 2.937±0.00 2.981±0.00 2.617±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000712 IBA resolution of meiotic recombination intermediates
GO:0000792 IDA heterochromatin
GO:0000819 IBA sister chromatid segregation
GO:0003677 IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003918 IDA:IEA DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 IPI protein kinase C binding
GO:0005524 IEA ATP binding
GO:0005634 IDA:IEA nucleus
GO:0005654 IDA nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0006200 IEA ATP catabolic process
GO:0006265 IDA:IEA DNA topological change
GO:0006268 IBA DNA unwinding involved in DNA replication
GO:0006312 IBA mitotic recombination
GO:0008022 IPI protein C-terminus binding
GO:0008301 IEA DNA binding, bending
GO:0009330 IBA DNA topoisomerase complex (ATP-hydrolyzing)
GO:0019899 IPI enzyme binding
GO:0042826 IPI histone deacetylase binding
GO:0044774 IBA mitotic DNA integrity checkpoint
GO:0046872 IEA metal ion binding
GO:0046982 IPI protein heterodimerization activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000017629 Top2b-001 protein_coding Mus_musculus 0 7256
ENSDART00000029024 top2b-201 protein_coding Danio_rerio 0 1781
ENSDART00000130695 top2b-001 protein_coding Danio_rerio 0 1781
ENSMUST00000068031 Top2a-001 protein_coding Mus_musculus 0 1467
ENSMUST00000161693 Top2b-006 protein_coding Mus_musculus 0 878
ENSMUST00000159302 Top2b-004 nonsense_mediated_decay Mus_musculus 0 723
ENSMUST00000160501 Top2b-003 protein_coding Mus_musculus 0 623
ENSMUST00000159987 Top2b-002 retained_intron Mus_musculus 0 595
ENSMUST00000163032 Top2b-005 retained_intron Mus_musculus 0 305

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