C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: endoplasmic reticulum (ER) to nucleus signalling 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000001059 Ern1-001 ENSMUSG00000020715 10090 - 11:106394650-106487796 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000001059
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000001059 4.716±1.65 36.748±3.79 3.834±1.07 2.521±1.03 5.987±2.57 3.920±1.86 2.343±0.29 3.708±1.13 8.020±4.84 5.582±3.34 1.676±0.21 14.487±5.98 9.142±4.06 2.473±1.20

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009B9 CIL_0009B9_0002 VISTA 11:105834084-106435839
CIL_0006GW CIL_0006GW_0002 CGP 11:106377656-106487852
CIL_0004WB CIL_0004WB_0003 CGP 11:106394650-106613423

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000287 ISS magnesium ion binding
GO:0004519 IDA endonuclease activity
GO:0004521 IDA endoribonuclease activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 ISS ATP binding
GO:0005637 IDA nuclear inner membrane
GO:0005739 IDA mitochondrion
GO:0005789 IDA endoplasmic reticulum membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 ISS protein phosphorylation
GO:0006987 ISS activation of signaling protein activity involved in unfolded protein response
GO:0007050 IDA cell cycle arrest
GO:0019899 IEA enzyme binding
GO:0030176 IEA integral component of endoplasmic reticulum membrane
GO:0030968 IDA endoplasmic reticulum unfolded protein response
GO:0042802 IEA identical protein binding
GO:0046777 IDA protein autophosphorylation
GO:0070055 IEA HAC1-type intron splice site recognition and cleavage
GO:0070059 IDA intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090305 IDA nucleic acid phosphodiester bond hydrolysis
GO:0090502 IDA RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900103 IEA positive regulation of endoplasmic reticulum unfolded protein response

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000433197 ERN1-001 protein_coding Homo_sapiens 0 3727
ENST00000577567 ERN1-005 processed_transcript Homo_sapiens 0 438
ENST00000579249 ERN1-006 retained_intron Homo_sapiens 0 292
ENST00000583896 ERN1-004 retained_intron Homo_sapiens 0 695
ENST00000584041 ERN1-003 retained_intron Homo_sapiens 0 477

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