C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: serine/threonine kinase 11
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000003152 Stk11-001 ENSMUSG00000003068 10090 + 10:80115803-80130682 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainHeartLiverLungMuscleOvaryPlacentaTestisENSMUST00000003152
Transcript ID Adipose Bladder Brain Heart Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000003152 43.592±4.81 25.706±0.99 23.217±2.47 28.446±0.00 29.831±5.22 62.674±10.75 33.696±3.49 26.060±0.00 22.375±3.97 20.851±1.80

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008XG CIL_0008XG_0002 VISTA 10:79539861-80142369
CIL_0000QW CIL_0000QW_0002 CGP 10:80057416-80130682
CIL_0005ZG CIL_0005ZG_0003 CGP 10:80115803-80140835

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000287 ISS magnesium ion binding
GO:0001558 IDA regulation of cell growth
GO:0001894 IMP tissue homeostasis
GO:0001944 IMP vasculature development
GO:0002039 ISS p53 binding
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 ISS ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 ISS mitochondrion
GO:0005829 IDA cytosol
GO:0006468 ISS protein phosphorylation
GO:0006914 IEA autophagy
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007050 ISS cell cycle arrest
GO:0007283 IEA spermatogenesis
GO:0007286 IMP spermatid development
GO:0007409 IMP axonogenesis
GO:0008285 IEA negative regulation of cell proliferation
GO:0010212 IDA response to ionizing radiation
GO:0016020 IDA membrane
GO:0030010 IMP establishment of cell polarity
GO:0030111 IMP regulation of Wnt signaling pathway
GO:0030275 IPI LRR domain binding
GO:0030295 IMP protein kinase activator activity
GO:0030308 IDA negative regulation of cell growth
GO:0030511 IMP positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032147 IDA activation of protein kinase activity
GO:0032403 IEA protein complex binding
GO:0033762 IEA response to glucagon
GO:0033993 IEA response to lipid
GO:0036398 IDA TCR signalosome
GO:0036399 IMP TCR signalosome assembly
GO:0042593 IMP glucose homeostasis
GO:0043234 IEA protein complex
GO:0043276 IEA anoikis
GO:0043434 IEA response to peptide hormone
GO:0045059 IMP positive thymic T cell selection
GO:0045722 IEA positive regulation of gluconeogenesis
GO:0046777 IDA protein autophosphorylation
GO:0050731 IMP positive regulation of peptidyl-tyrosine phosphorylation
GO:0050772 IGI positive regulation of axonogenesis
GO:0050852 IGI T cell receptor signaling pathway
GO:0051291 IEA protein heterooligomerization
GO:0051645 IMP Golgi localization
GO:0051896 IMP regulation of protein kinase B signaling
GO:0060070 IMP canonical Wnt signaling pathway
GO:0060770 IMP negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0070062 IEA extracellular vesicular exosome
GO:0072332 ISS intrinsic apoptotic signaling pathway by p53 class mediator

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000067736 stk11-001 protein_coding Danio_rerio 0 806
ENST00000326873 STK11-001 protein_coding Homo_sapiens 0 1290
ENST00000585851 STK11-004 protein_coding Homo_sapiens 0 372
ENST00000586243 STK11-201 protein_coding Homo_sapiens 0 1297
ENST00000586358 STK11-005 retained_intron Homo_sapiens 0 468
ENST00000589152 STK11-002 retained_intron Homo_sapiens 0 974
ENST00000591133 STK11-006 retained_intron Homo_sapiens 0 470
ENST00000593219 STK11-009 nonsense_mediated_decay Homo_sapiens 0 370

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