C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: histone deacetylase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000019911 Hdac2-001 ENSMUSG00000019777 10090 + 10:36974544-37001889 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000019911
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000019911 11.109±4.76 48.438±13.07 22.485±1.24 47.095±6.99 9.883±5.56 9.298±1.78 8.428±0.62 7.380±1.47 11.239±8.83 12.769±4.04 20.136±0.85 30.409±18.60 24.289±10.56 11.991±10.79

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007P5 CIL_0007P5_000A UCNEbase 10:36379394-37135425

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000118 TAS histone deacetylase complex
GO:0000122 IGI negative regulation of transcription from RNA polymerase II promoter
GO:0000785 IEA chromatin
GO:0000790 IDA nuclear chromatin
GO:0000792 IDA heterochromatin
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 IEA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001047 IEA core promoter binding
GO:0001103 IEA RNA polymerase II repressing transcription factor binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0004407 TAS histone deacetylase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005657 IDA replication fork
GO:0005667 IPI transcription factor complex
GO:0005737 TAS cytoplasm
GO:0006344 IEA maintenance of chromatin silencing
GO:0006351 IEA transcription, DNA-templated
GO:0006476 IDA protein deacetylation
GO:0008134 TAS transcription factor binding
GO:0008284 IGI positive regulation of cell proliferation
GO:0009913 IGI epidermal cell differentiation
GO:0010870 IEA positive regulation of receptor biosynthetic process
GO:0010977 IDA negative regulation of neuron projection development
GO:0016358 IMP dendrite development
GO:0016568 TAS chromatin modification
GO:0016575 IGI histone deacetylation
GO:0016580 IEA Sin3 complex
GO:0016581 IEA NuRD complex
GO:0017053 IPI transcriptional repressor complex
GO:0019213 IDA deacetylase activity
GO:0019899 IPI enzyme binding
GO:0021766 IGI hippocampus development
GO:0030182 IGI neuron differentiation
GO:0031072 IEA heat shock protein binding
GO:0031490 IDA chromatin DNA binding
GO:0031492 IEA nucleosomal DNA binding
GO:0032041 IEA NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032922 IDA circadian regulation of gene expression
GO:0033558 IDA protein deacetylase activity
GO:0034605 IEA cellular response to heat
GO:0035098 ISS ESC/E(Z) complex
GO:0035851 IPI Krueppel-associated box domain binding
GO:0042220 IEA response to cocaine
GO:0042475 IGI odontogenesis of dentin-containing tooth
GO:0042493 IEA response to drug
GO:0042733 IGI embryonic digit morphogenesis
GO:0043044 IEA ATP-dependent chromatin remodeling
GO:0043066 IGI negative regulation of apoptotic process
GO:0043234 IEA protein complex
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IEA sequence-specific DNA binding
GO:0044822 IEA poly(A) RNA binding
GO:0045862 IEA positive regulation of proteolysis
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046969 IEA NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 IEA NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048714 IGI positive regulation of oligodendrocyte differentiation
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051896 IMP regulation of protein kinase B signaling
GO:0055013 IMP cardiac muscle cell development
GO:0060044 IMP negative regulation of cardiac muscle cell proliferation
GO:0060297 IMP regulation of sarcomere organization
GO:0060789 IGI hair follicle placode formation
GO:0061029 IGI eyelid development in camera-type eye
GO:0061198 IGI fungiform papilla formation
GO:0070932 IDA histone H3 deacetylation
GO:0070933 IDA histone H4 deacetylation
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway
GO:0090311 IGI regulation of protein deacetylation
GO:0097372 IEA NAD-dependent histone deacetylase activity (H3-K18 specific)
GO:2001243 IGI negative regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000368632 HDAC2-003 protein_coding Homo_sapiens 0 2289
ENST00000425835 HDAC2-002 protein_coding Homo_sapiens 0 660
ENST00000518690 HDAC2-006 protein_coding Homo_sapiens 0 368
ENST00000518756 HDAC2-016 retained_intron Homo_sapiens 0 326
ENST00000519065 HDAC2-001 protein_coding Homo_sapiens 0 2383
ENST00000519108 HDAC2-004 protein_coding Homo_sapiens 0 2290
ENST00000520170 HDAC2-013 retained_intron Homo_sapiens 0 263
ENST00000520746 HDAC2-017 retained_intron Homo_sapiens 0 610
ENST00000520895 HDAC2-010 protein_coding Homo_sapiens 0 318
ENST00000521163 HDAC2-015 protein_coding Homo_sapiens 0 374
ENST00000521233 HDAC2-014 retained_intron Homo_sapiens 0 431
ENST00000521610 HDAC2-008 protein_coding Homo_sapiens 0 484
ENST00000522371 HDAC2-012 protein_coding Homo_sapiens 0 429
ENST00000523240 HDAC2-007 protein_coding Homo_sapiens 0 346
ENST00000523334 HDAC2-005 retained_intron Homo_sapiens 0 1223
ENST00000523628 HDAC2-011 protein_coding Homo_sapiens 0 501
ENST00000524334 HDAC2-009 protein_coding Homo_sapiens 0 285

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