C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: SHANK-associated RH domain interacting protein
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000023211 Sharpin-001 ENSMUSG00000022552 10090 - 15:76347040-76351111 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000023211
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000023211 15.138±0.72 22.782±2.95 22.497±2.53 14.852±7.46 16.834±6.50 24.054±1.77 9.533±2.03 19.042±1.22 14.491±1.79 18.385±1.02 14.198±0.97 18.417±8.36 7.770±2.99 15.950±7.97

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007SS CIL_0007SS_0002 VISTA 15:76102685-76704351
CIL_00026W CIL_00026W_0002 CGP 15:76343523-76351111
CIL_0006Y3 CIL_0006Y3_0003 CGP 15:76347040-76354380

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005829 ISS cytosol
GO:0007005 IMP mitochondrion organization
GO:0007420 IEA brain development
GO:0008270 IEA zinc ion binding
GO:0008544 IMP epidermis development
GO:0010803 ISS regulation of tumor necrosis factor-mediated signaling pathway
GO:0014069 IEA postsynaptic density
GO:0030054 IEA cell junction
GO:0030262 IMP apoptotic nuclear changes
GO:0030425 IEA dendrite
GO:0031424 IMP keratinization
GO:0031593 ISS polyubiquitin binding
GO:0032403 IEA protein complex binding
GO:0042802 IEA identical protein binding
GO:0043123 ISS positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050728 IMP negative regulation of inflammatory response
GO:0051260 IEA protein homooligomerization
GO:0071797 ISS LUBAC complex
GO:0097039 ISS protein linear polyubiquitination
GO:2000348 ISS regulation of CD40 signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000359551 SHARPIN-002 nonsense_mediated_decay Homo_sapiens 1.99965e-42 178
ENST00000398712 SHARPIN-001 protein_coding Homo_sapiens 0 647
ENST00000532536 SHARPIN-011 protein_coding Homo_sapiens 0 191

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