C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cyclin-dependent kinase inhibitor 1A (P21)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000023829 Cdkn1a-001 ENSMUSG00000023067 10090 + 17:29093772-29100722 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000023829
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000023829 30.693±19.86 21.250±1.34 16.698±3.33 6.585±3.21 19.023±3.57 118.302±2.63 12.252±0.95 5.825±0.39 6.752±6.87 44.547±1.08 5.142±1.98 27.150±9.92 8.947±3.77 3.102±1.91

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002YD CIL_0002YD_0002 CGP 17:29090979-29148980

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000079 IMP regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 IEA G1/S transition of mitotic cell cycle
GO:0000086 IEA G2/M transition of mitotic cell cycle
GO:0000307 IPI cyclin-dependent protein kinase holoenzyme complex
GO:0004861 IDA cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0006468 IEA protein phosphorylation
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0006977 IEA DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050 IDA cell cycle arrest
GO:0007265 IEA Ras protein signal transduction
GO:0007346 IMP regulation of mitotic cell cycle
GO:0008285 IMP negative regulation of cell proliferation
GO:0009411 IMP response to UV
GO:0009636 IEA response to toxic substance
GO:0010033 IEA response to organic substance
GO:0010165 IEA response to X-ray
GO:0010243 IEA response to organonitrogen compound
GO:0010629 IMP negative regulation of gene expression
GO:0014070 IEA response to organic cyclic compound
GO:0019912 IEA cyclin-dependent protein kinase activating kinase activity
GO:0030308 IEA negative regulation of cell growth
GO:0030332 IDA cyclin binding
GO:0030890 IGI positive regulation of B cell proliferation
GO:0031100 IEA organ regeneration
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031668 IEA cellular response to extracellular stimulus
GO:0032403 IEA protein complex binding
GO:0033158 IMP regulation of protein import into nucleus, translocation
GO:0034605 IEA cellular response to heat
GO:0042326 IEA negative regulation of phosphorylation
GO:0042493 IEA response to drug
GO:0042771 IMP intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 IEA negative regulation of apoptotic process
GO:0043068 IMP positive regulation of programmed cell death
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0045736 IDA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045860 IEA positive regulation of protein kinase activity
GO:0046685 IEA response to arsenic-containing substance
GO:0046872 IEA metal ion binding
GO:0048146 IEA positive regulation of fibroblast proliferation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0051384 IEA response to glucocorticoid
GO:0051412 IEA response to corticosterone
GO:0051726 IDA regulation of cell cycle
GO:0055093 IEA response to hyperoxia
GO:0060574 IEA intestinal epithelial cell maturation
GO:0070557 ISS PCNA-p21 complex
GO:0071479 IEA cellular response to ionizing radiation
GO:0071850 IDA mitotic cell cycle arrest
GO:0090398 IEA cellular senescence
GO:2000278 IMP regulation of DNA biosynthetic process
GO:2000379 IEA positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000244741 CDKN1A-001 protein_coding Homo_sapiens 0 309
ENST00000373711 CDKN1A-002 protein_coding Homo_sapiens 0 309
ENST00000405375 CDKN1A-201 protein_coding Homo_sapiens 0 309
ENST00000448526 CDKN1A-202 protein_coding Homo_sapiens 0 309
ENST00000615513 CDKN1A-203 protein_coding Homo_sapiens 0 309

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