C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: SMAD family member 7
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000026999 Smad7-001 ENSMUSG00000025880 10090 + 18:75367529-75395935 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000026999
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000026999 2.795±0.88 2.102±0.83 4.603±0.32 1.777±1.26 5.103±2.06 8.596±1.57 3.215±0.80 5.611±0.68 0.952±0.35 17.242±0.52 1.357±0.28 4.371±1.53 6.054±2.77 0.165±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008P6 CIL_0008P6_0002 VISTA 18:75201597-75805830
CIL_0007UR CIL_0007UR_0002 VISTA 18:75202363-75803667

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001657 IEP ureteric bud development
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005518 IPI collagen binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0005913 IEA cell-cell adherens junction
GO:0006351 IEA transcription, DNA-templated
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0008013 IEA beta-catenin binding
GO:0010801 IMP negative regulation of peptidyl-threonine phosphorylation
GO:0010944 IEA negative regulation of transcription by competitive promoter binding
GO:0016342 IEA catenin complex
GO:0017015 IC regulation of transforming growth factor beta receptor signaling pathway
GO:0022409 IMP positive regulation of cell-cell adhesion
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 IDA negative regulation of BMP signaling pathway
GO:0030617 IEA transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0031397 IEA negative regulation of protein ubiquitination
GO:0031398 IEA positive regulation of protein ubiquitination
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032436 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032925 IEA regulation of activin receptor signaling pathway
GO:0033137 IMP negative regulation of peptidyl-serine phosphorylation
GO:0034333 IEA adherens junction assembly
GO:0034616 IEA response to laminar fluid shear stress
GO:0034629 IEA cellular protein complex localization
GO:0034713 IEA type I transforming growth factor beta receptor binding
GO:0035556 IEA intracellular signal transduction
GO:0043234 IDA protein complex
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0046872 IEA metal ion binding
GO:0048185 IEA activin binding
GO:0048844 IMP artery morphogenesis
GO:0050821 IEA protein stabilization
GO:0051444 IEA negative regulation of ubiquitin-protein transferase activity
GO:0055010 IMP ventricular cardiac muscle tissue morphogenesis
GO:0055117 IMP regulation of cardiac muscle contraction
GO:0060373 IC regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060389 IMP pathway-restricted SMAD protein phosphorylation
GO:0060394 IEA negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060412 IMP ventricular septum morphogenesis
GO:0070411 IEA I-SMAD binding
GO:0071560 IMP cellular response to transforming growth factor beta stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000262158 SMAD7-001 protein_coding Homo_sapiens 0 2556
ENST00000545051 SMAD7-003 retained_intron Homo_sapiens 0 1027
ENST00000585986 SMAD7-006 processed_transcript Homo_sapiens 0 769
ENST00000586093 SMAD7-007 protein_coding Homo_sapiens 0 809
ENST00000587336 SMAD7-004 processed_transcript Homo_sapiens 0 791
ENST00000588190 SMAD7-008 processed_transcript Homo_sapiens 0 440
ENST00000589634 SMAD7-005 protein_coding Homo_sapiens 0 2025
ENST00000591805 SMAD7-002 protein_coding Homo_sapiens 0 1116

Loading