C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: bone morphogenetic protein 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000028836 Bmp2-001 ENSMUSG00000027358 10090 + 2:133552159-133562885 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000028836
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000028836 1.554±0.41 8.862±1.21 11.354±1.13 0.404±0.13 2.074±0.90 21.030±3.20 0.382±0.13 0.970±0.28 1.804±0.61 2.509±0.34 0.344±0.08 9.596±3.79 0.658±0.28 0.053±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001J1 CIL_0001J1_0002 CGP 2:132904389-133562885
CIL_0002W0 CIL_0002W0_0002 CGP 2:133552159-134554368

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000187 IEA activation of MAPK activity
GO:0001649 IGI osteoblast differentiation
GO:0001658 IGI branching involved in ureteric bud morphogenesis
GO:0001666 IMP response to hypoxia
GO:0001701 IMP in utero embryonic development
GO:0001837 ISO epithelial to mesenchymal transition
GO:0001934 ISO positive regulation of protein phosphorylation
GO:0001938 IEA positive regulation of endothelial cell proliferation
GO:0002062 IEA chondrocyte differentiation
GO:0003130 IEA BMP signaling pathway involved in heart induction
GO:0003181 IMP atrioventricular valve morphogenesis
GO:0003203 IMP endocardial cushion morphogenesis
GO:0003308 IEA negative regulation of Wnt signaling pathway involved in heart development
GO:0004745 IDA retinol dehydrogenase activity
GO:0005125 TAS cytokine activity
GO:0005515 IPI protein binding
GO:0005615 IDA extracellular space
GO:0006029 IGI proteoglycan metabolic process
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0006954 IEP inflammatory response
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007219 IMP Notch signaling pathway
GO:0007507 IMP heart development
GO:0008083 IEA growth factor activity
GO:0008285 IGI negative regulation of cell proliferation
GO:0009887 IMP organ morphogenesis
GO:0009986 IEA cell surface
GO:0010628 IDA positive regulation of gene expression
GO:0010629 IDA negative regulation of gene expression
GO:0010718 IMP positive regulation of epithelial to mesenchymal transition
GO:0010862 ISS positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010894 IEA negative regulation of steroid biosynthetic process
GO:0010922 ISO positive regulation of phosphatase activity
GO:0019211 ISO phosphatase activator activity
GO:0021537 ISO telencephalon development
GO:0021978 IGI telencephalon regionalization
GO:0030177 IDA positive regulation of Wnt signaling pathway
GO:0030282 IDA bone mineralization
GO:0030335 IMP positive regulation of cell migration
GO:0030501 IEA positive regulation of bone mineralization
GO:0030509 IDA BMP signaling pathway
GO:0031648 IDA protein destabilization
GO:0032348 IEA negative regulation of aldosterone biosynthetic process
GO:0033690 IMP positive regulation of osteoblast proliferation
GO:0035051 ISO cardiocyte differentiation
GO:0035054 IMP embryonic heart tube anterior/posterior pattern specification
GO:0035630 IEA bone mineralization involved in bone maturation
GO:0040007 IEA growth
GO:0042475 IDA odontogenesis of dentin-containing tooth
GO:0042482 IDA positive regulation of odontogenesis
GO:0042487 IGI regulation of odontogenesis of dentin-containing tooth
GO:0043065 ISO positive regulation of apoptotic process
GO:0043410 IEA positive regulation of MAPK cascade
GO:0043569 IEA negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045165 IMP cell fate commitment
GO:0045597 IDA positive regulation of cell differentiation
GO:0045600 IDA positive regulation of fat cell differentiation
GO:0045666 IDA positive regulation of neuron differentiation
GO:0045669 IDA positive regulation of osteoblast differentiation
GO:0045778 IDA positive regulation of ossification
GO:0045786 IEA negative regulation of cell cycle
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IEA SMAD binding
GO:0046982 ISO protein heterodimerization activity
GO:0048711 IDA positive regulation of astrocyte differentiation
GO:0048762 ISS mesenchymal cell differentiation
GO:0048839 IDA inner ear development
GO:0050769 ISO positive regulation of neurogenesis
GO:0051042 IEA negative regulation of calcium-independent cell-cell adhesion
GO:0055007 ISS cardiac muscle cell differentiation
GO:0055008 IMP cardiac muscle tissue morphogenesis
GO:0055114 IDA oxidation-reduction process
GO:0060039 IMP pericardium development
GO:0060128 IDA corticotropin hormone secreting cell differentiation
GO:0060129 IDA thyroid-stimulating hormone-secreting cell differentiation
GO:0060317 IEA cardiac epithelial to mesenchymal transition
GO:0060389 IEA pathway-restricted SMAD protein phosphorylation
GO:0060395 ISS SMAD protein signal transduction
GO:0060485 ISS mesenchyme development
GO:0060804 IDA positive regulation of Wnt signaling pathway by BMP signaling pathway
GO:0061036 IDA positive regulation of cartilage development
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0070700 ISO BMP receptor binding
GO:0071363 IDA cellular response to growth factor stimulus
GO:0071407 IDA cellular response to organic cyclic compound
GO:0071773 IEA cellular response to BMP stimulus
GO:0072138 IMP mesenchymal cell proliferation involved in ureteric bud development
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:1900745 IEA positive regulation of p38MAPK cascade
GO:1901522 IEA positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:2000065 IEA negative regulation of cortisol biosynthetic process
GO:2000726 IEA negative regulation of cardiac muscle cell differentiation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000378827 BMP2-001 protein_coding Homo_sapiens 0 2841

Loading